Inglot A D, Popik W, Piasecki E, Czyrski J
Mol Biol Rep. 1986;11(1):37-42. doi: 10.1007/BF00417593.
'Molecular sandwiches' composed of two aromatic amino acids separated by a hydrophilic one were found on eleven subspecies of human interferon alpha, on murine interferon alpha 2, and human interferon beta 1. In addition, another type of the sandwiches was found on several species of interferon. This confirms and extends the observations concerning the similarities between some interferons and several classical hormones. Furthermore, we are presenting evidence that a distinct type of the 'molecular sandwiches': Tyr-Cys...Cys and/or Cys...Cys-Cys...Cys, that participate in formation of disulfide bonds, is a characteristic marker of most, if not all of the growth-promoting hormones including growth factors. The 'sandwiches' appear to be important for receptor binding.
在人α干扰素的11个亚种、鼠α干扰素2和人β干扰素1中发现了由两个芳香族氨基酸被一个亲水性氨基酸隔开组成的“分子三明治”。此外，在几种干扰素中还发现了另一种类型的三明治。这证实并扩展了有关某些干扰素与几种经典激素之间相似性的观察结果。此外，我们还提供证据表明，一种独特类型的“分子三明治”：参与二硫键形成的Tyr-Cys...Cys和/或Cys...Cys-Cys...Cys，是大多数（如果不是全部）包括生长因子在内的促生长激素的特征性标记。这些“三明治”似乎对受体结合很重要。
