“分子三明治”作为干扰素、促黑激素、促肾上腺皮质激素、促黄体生成素释放激素、髓鞘碱性蛋白和白蛋白结构与功能相似性的基础。
'Molecular sandwiches' as a basis for structural and functional similarities for interferons, MSH, ACTH, LHRH, myelin basic protein, and albumins.
作者信息
Root-Bernstein R S
出版信息
FEBS Lett. 1984 Mar 26;168(2):208-12. doi: 10.1016/0014-5793(84)80247-1.
Sequential similarities between the tryptophan peptide of myelin basic protein (residues 111-121), luteinizing hormone releasing hormone, melanotropin, adrenocorticotropin (residues 1-13), human leukocyte interferon (residues 28-40), and various segments of human and bovine serum albumin and hen ovalbumin are presented. It is suggested that these structural similarities may explain observations concerning common functional characteristics such as serotonin modulation, immunological activity with the adjuvant muramyl dipeptide, immunological cross-reactivity, and the possible MSH-ACTH-like activity of a pepsin-derived peptide of interferon.
本文呈现了髓鞘碱性蛋白的色氨酸肽（第111 - 121位氨基酸残基）、促黄体生成素释放激素、促黑素、促肾上腺皮质激素（第1 - 13位氨基酸残基）、人白细胞干扰素（第28 - 40位氨基酸残基）以及人血清白蛋白、牛血清白蛋白和鸡卵白蛋白的各个片段之间的序列相似性。有人提出，这些结构相似性或许可以解释一些关于共同功能特征的观察结果，比如血清素调节、与佐剂胞壁酰二肽的免疫活性、免疫交叉反应性，以及干扰素的一种胃蛋白酶衍生肽可能具有的促黑素 - 促肾上腺皮质激素样活性。
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