新型人类白细胞干扰素亚型及α干扰素基因的结构比较

Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes.

作者信息

Gren E, Berzin V, Jansone I, Tsimanis A, Vishnevsky Y, Apsalons U

出版信息

J Interferon Res. 1984 Fall;4(4):609-17. doi: 10.1089/jir.1984.4.609.

DOI:10.1089/jir.1984.4.609

Abstract

In the cDNA library of virus-induced human leukocytes a novel subtype of IFN-alpha gene has been identified and sequenced, named IFN-alpha-N. A comparison of nucleotide sequences within the genes coding for different subtypes of human leukocyte interferon (IFN-alpha) has revealed the natural hybrid structure of individual alpha-IFNs-H,B,F, and N. Certain regions of the genes for IFN-alpha-H,B,F,N show a homology with one of the two structurally distinct groups of leukocyte interferons--either IFN-alpha-A,D or IFN-alpha-C,C1 utilized as reference standards.

摘要

在病毒诱导的人白细胞cDNA文库中，已鉴定并测序了一种新型的IFN-α基因亚型，命名为IFN-α-N。对编码人白细胞干扰素（IFN-α）不同亚型的基因内核苷酸序列进行比较，揭示了单个α-干扰素-H、B、F和N的天然杂交结构。IFN-α-H、B、F、N基因的某些区域与两种结构不同的白细胞干扰素组之一具有同源性——即用作参考标准的IFN-α-A、D或IFN-α-C、C1。