British Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC V6Z 2A9, Canada; Department of Medicine, University of British Columbia, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada.
British Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC V6Z 2A9, Canada; Department of Medicine, University of British Columbia, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada; School of Medicine, Yale University, 333 Cedar Street, New Haven, CT 06510, United States.
Int J Drug Policy. 2022 Apr;102:103592. doi: 10.1016/j.drugpo.2022.103592. Epub 2022 Jan 31.
The dominant focus of North America's current overdose crisis has been opioids, resulting in considerable research and harm reduction efforts to address opioid-related overdose risks. Less attention has been paid to people who use stimulants (PWUS) despite recent increases in stimulant use and stimulant-involved overdoses (i.e., "overamping"). Stimulant users' definitions, risk factors and experiences of, and responses to, overamping are poorly understood, thereby putting PWUS at heightened risk of adverse health outcomes. This study explores how PWUS understand, experience, and respond to overamping.
In-depth qualitative interviews were conducted with 61 PWUS in Vancouver, Canada's Downtown Eastside neighbourhood. Thematic analysis of interviews focused on contextualizing stimulant overdoses, including how PWUS understand, define, experience, and respond to overamping.
Participants associated overamping experiences with commonly identified signs and symptoms, such as rapid onset, elevated heart rate, incontinence, and audiovisua hallucinations, but also reported more serious indicators of overamping, such as unconsciousness, cardiac arrests and seizures. Our findings demonstrate that, among PWUS, there was no unified understanding of overamping such as with opioid overdose and individual experiences had substantial variation in severity and presentation. This impacted the ability to adequately respond to stimulant overdoses, which were primarily self-managed through methods including stabilizing breathing, polysubstance use, and cold showers.
Given the growing role of stimulants in North America's overdose crisis, there is an urgent need to improve the identification of stimulant overdoses in real world settings. Our findings identify a gap in current understandings of stimulant overdose, and demonstrate the need for public health and harm reduction interventions to better address overamp risk among PWUS, including harm reduction campaigns to disseminate information regarding identifying signs of, and proper responses to, overamping.
目前北美的主要关注点是阿片类药物的过量问题,因此针对阿片类药物相关的过量风险已经开展了大量的研究和减少危害的工作。尽管最近兴奋剂的使用和涉及兴奋剂的过量(即“过量使用”)有所增加,但人们对使用兴奋剂者(PWUS)的关注度较低。对兴奋剂使用者对过量使用的定义、风险因素、体验和反应知之甚少,这使得 PWUS面临更高的不良健康后果风险。本研究探讨了 PWUS 如何理解、体验和应对过量使用。
在加拿大温哥华市中心东区,对 61 名 PWUS 进行了深入的定性访谈。对访谈的主题分析侧重于使兴奋剂过量问题背景化,包括 PWUS 如何理解、定义、体验和应对过量使用。
参与者将过量使用的经历与常见的体征和症状联系起来,如快速发作、心率升高、尿失禁和视听幻觉,但也报告了更严重的过量使用迹象,如失去意识、心脏骤停和癫痫发作。我们的研究结果表明,在 PWUS 中,对于过量使用,没有像阿片类药物过量那样的统一理解,而且个体的体验在严重程度和表现上存在很大差异。这影响了对兴奋剂过量的充分反应,主要通过稳定呼吸、多种物质使用和冷水淋浴等方法进行自我管理。
鉴于兴奋剂在北美的过量危机中扮演的角色越来越重要,迫切需要提高在现实环境中识别兴奋剂过量的能力。我们的研究结果表明,目前对兴奋剂过量的理解存在差距,并表明需要公共卫生和减少危害的干预措施,以更好地解决 PWUS 中的过量使用风险,包括减少危害的运动,传播有关识别和正确应对过量使用的迹象的信息。