School of Dental Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, UK.
Department of Economics, Swedish University of Agricultural Economics, Uppsala, Sweden.
Health Qual Life Outcomes. 2022 Feb 3;20(1):18. doi: 10.1186/s12955-022-01918-w.
This study develops an adolescent value set for a child-centred dental caries-specific measure of oral health-related quality of life (OHRQoL) based upon CARIES-QC (Caries Impacts and Experiences Questionnaire for Children). This study develops a new approach to valuing child health by eliciting adolescent preferences and anchoring these onto the 1-0 full health-dead QALY (quality adjusted life year) scale using ordinal adult preferences.
Two online surveys were created to elicit preferences for the CARIES-QC classification system. The first comprised best-worst scaling (BWS) tasks for completion by adolescents aged 11-16 years. The second comprised discrete choice experiment tasks with a duration attribute (DCE) for completion by adults aged over 18 years. Preferences were modelled using the conditional logit model. Mapping regressions anchored the adolescent BWS data onto the QALY scale using adult DCE values, since the BWS survey data alone cannot generate anchored values.
723 adolescents completed the BWS survey and 626 adults completed the DCE survey. The samples were representative of UK adolescent and adult populations. Fully consistent and robust models were produced for both BWS and DCE data. BWS preferences were mapped onto DCE values, resulting utility estimates for each health state defined by the classification system.
This is the first measure with predetermined scoring based on preferences to be developed specifically for use in child oral health research, and uses a novel technique to generate a value set using adolescent preferences. The estimates can be used to generate QALYs in economic evaluations of interventions to improve children's oral health.
本研究基于 CARIES-QC（儿童龋病影响和体验问卷）为儿童为中心的龋齿特异性口腔健康相关生活质量（OHRQoL）测量方法开发青少年价值观。本研究通过青少年偏好，提出一种新的儿童健康估值方法，并使用有序成人偏好将这些偏好锚定到 1-0 全健康-死亡 QALY（质量调整生命年）量表上。
设计了两个在线调查来获取 CARIES-QC 分类系统的偏好。第一个由 11-16 岁青少年完成的最佳最差标度（BWS）任务组成。第二个由年龄在 18 岁以上的成年人完成的具有持续时间属性的离散选择实验任务（DCE）组成。偏好使用条件对数模型进行建模。映射回归使用成人 DCE 值将青少年 BWS 数据锚定到 QALY 量表上，因为仅 BWS 调查数据无法生成锚定值。
723 名青少年完成了 BWS 调查，626 名成年人完成了 DCE 调查。样本代表了英国青少年和成年人的人群。为 BWS 和 DCE 数据生成了完全一致和稳健的模型。BWS 偏好被映射到 DCE 值上，从而为分类系统定义的每个健康状态生成效用估计。
这是第一个基于偏好为儿童口腔健康研究专门开发的具有预定评分的测量方法，并使用了一种新的技术来使用青少年偏好生成价值集。这些估计可用于生成改善儿童口腔健康干预措施的经济评估中的 QALYs。
