Yan Zhaopeng, Wang Rui, Su Qi
Department of General Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Department of Critical Medicine, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Transl Cancer Res. 2019 Nov;8(7):2621-2623. doi: 10.21037/tcr.2019.10.19.
Cancer is a heterogenetic disease. Although multiple hypotheses and models have been indicated, there is still no robust method to distinguish the heterogeneity of cancer. Evidence has been provided showing that cancer stem cells (CSCs) play an important role in the origin and progression of cancer. In this opinion article, based on the theory of CSCs, we propose a novel CSC-based classification model (CSCCM) to explain the origin and progression of colorectal cancer, which would explain some confusing clinical phenomena and distinguish the heterogeneity of colorectal cancer from its origin. We further suggest that this model can presently be incorporated into the cancer progression theory.
癌症是一种异质性疾病。尽管已经提出了多种假说和模型，但仍没有可靠的方法来区分癌症的异质性。已有证据表明，癌症干细胞（CSCs）在癌症的发生和发展中起着重要作用。在这篇观点文章中，基于癌症干细胞理论，我们提出了一种新的基于癌症干细胞的分类模型（CSCCM）来解释结直肠癌的发生和发展，这将解释一些令人困惑的临床现象，并从起源上区分结直肠癌的异质性。我们进一步认为，目前该模型可以纳入癌症进展理论。
