Liu Wen, Chen Qunxi, Mao Minjie, Han Runkun, Liu Yijun, Wang Xueping
Department of Laboratory Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Department of Pathology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Transl Cancer Res. 2020 Oct;9(10):5925-5939. doi: 10.21037/tcr-20-966.
The level of ferritin has been shown to be associated with the prognosis of various tumors. In this study, we proposed prognostic indicator, named ferritin/globulin ratio (FGR), and to evaluate the important value in hepatocellular carcinoma (HCC).
A total of 472 HCC patients and 219 healthy controls were concluded in our retrospective study. The clinical characteristics were analyzed in these patients. The optimal cutoff value of the prognostic factors (α-fetoprotein, alanine aminotransferase, aspartate aminotransferase, ferritin, globulin and FGR) were determined by using receiver operating characteristic curve analysis, and then analyzed by univariate and multivariate Cox hazard models to evaluate the prognostic significance.
Serum ferritin, globulin and FGR levels were significantly higher in HCC patients than in healthy controls. Multivariate analysis showed that FGR was a significant and independent risk factor OS (HR =1.575; 95% CI: 1.122-2.212; P=0.009) and DFS (HR =1.569; 95% CI: 1.117-2.204; P=0.009) in whole patients. Furthermore, we also classified the data according to α-fetoprotein (AFP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), highly significant differences of FGR were observed between the two groups in OS and DFS. High FGR levels were associated with poor OS and DFS in HCC patients.
The serum FGR levels may serve as a significant predictor of prognosis in HCC patients.
铁蛋白水平已被证明与各种肿瘤的预后相关。在本研究中，我们提出了一种名为铁蛋白/球蛋白比值（FGR）的预后指标，并评估其在肝细胞癌（HCC）中的重要价值。
我们的回顾性研究纳入了472例HCC患者和219例健康对照。分析了这些患者的临床特征。通过受试者工作特征曲线分析确定预后因素（甲胎蛋白、丙氨酸转氨酶、天冬氨酸转氨酶、铁蛋白、球蛋白和FGR）的最佳截断值，然后通过单因素和多因素Cox风险模型进行分析，以评估预后意义。
HCC患者的血清铁蛋白、球蛋白和FGR水平显著高于健康对照。多因素分析显示，FGR是全组患者总生存期（OS）（HR =1.575；95%CI：1.122-2.212；P=0.009）和无病生存期（DFS）（HR =1.569；95%CI：1.117-2.204；P=0.009）的显著独立危险因素。此外，我们还根据甲胎蛋白（AFP）、丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）对数据进行分类，两组在OS和DFS方面FGR存在高度显著差异。高FGR水平与HCC患者较差的OS和DFS相关。
血清FGR水平可能是HCC患者预后的重要预测指标。
