Department of internal medicine, Albany medical center, Albany, NY, USA.
Department of radiology, Albany medical center, Albany, NY, USA.
J Clin Transl Hepatol. 2015 Sep 28;3(3):169-81. doi: 10.14218/JCTH.2015.00012. Epub 2015 Sep 15.
Tumors of the liver and biliary tree, mainly hepatocellular carcinoma and cholangiocarcinoma, are the second leading cause of cancer related death worldwide and the sixth leading cause of cancer related death among men in developed countries. Recent developments in biomarkers and imaging modalities have enhanced early detection and accurate diagnosis of these highly fatal malignancies. These advances include serological testing, micro-ribonucleic acids, fluorescence in situ hybridization, contrast-enhanced ultrasound, and hepatobiliary-phase magnetic resonance imaging. In addition, there have been major developments in the surgical and nonsurgical management of these tumors, including expansion of the liver transplantation criteria, new locoregional treatments, and molecularly targeted therapies. In this article, we review various types of hepatobiliary tumors and discuss new developments in their diagnosis and management.
肝脏和胆道系统肿瘤，主要是肝细胞癌和胆管癌，是全球癌症相关死亡的第二大主要原因，也是发达国家男性癌症相关死亡的第六大主要原因。生物标志物和成像方式的最新进展增强了这些高度致命性恶性肿瘤的早期检测和准确诊断。这些进展包括血清学检测、微核糖核酸、荧光原位杂交、超声造影、肝胆期磁共振成像。此外，在这些肿瘤的手术和非手术治疗方面也取得了重大进展，包括扩大肝移植标准、新的局部治疗方法和分子靶向治疗。在本文中，我们将回顾各种类型的肝胆肿瘤，并讨论其诊断和治疗的新进展。
