Della Corte Luigi, Giampaolino Pierluigi, Mercorio Antonio, Riemma Gaetano, Schiattarella Antonio, De Franciscis Pasquale, Bifulco Giuseppe
Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.
Department of Public Health, University of Naples Federico II, Naples, Italy.
Transl Cancer Res. 2020 Dec;9(12):7725-7733. doi: 10.21037/tcr.2020.04.21.
Endometrial cancer (EC) is the most common gynecological neoplasm in developed countries. In literature, there are discordant data regarding the therapeutic value of systematic lymphadenectomy whereas the importance of lymph node status for determining prognosis and the need for adjuvant treatment is undoubted. Given the low risk of lymph-node metastases in the apparent early-stage disease and the significant surgical and postoperative risks when performing a complete pelvic lymphadenectomy, the surgical approach in these patients is controversial, ranging from no nodal evaluation to comprehensive pelvic and aortic lymphadenectomy. The recent introduction of sentinel node mapping represents the mid-way between the execution and omission of node dissection in EC patients. Indeed, the sentinel node mapping has rapidly emerged as an alternative to complete lymphadenectomy to reduce morbidity. In the present review, we discuss the role of sentinel node mapping in the surgical management of EC evaluating all aspects of this procedure.
子宫内膜癌（EC）是发达国家最常见的妇科肿瘤。在文献中，关于系统性淋巴结清扫术的治疗价值存在不一致的数据，而淋巴结状态对于确定预后的重要性以及辅助治疗的必要性是毋庸置疑的。鉴于在明显的早期疾病中淋巴结转移风险较低，以及进行完全盆腔淋巴结清扫术时存在显著的手术和术后风险，这些患者的手术方式存在争议，范围从不进行淋巴结评估到全面的盆腔和主动脉旁淋巴结清扫术。最近引入的前哨淋巴结 mapping 代表了 EC 患者淋巴结清扫术实施与省略之间的中间路线。事实上，前哨淋巴结 mapping 已迅速成为完全淋巴结清扫术的替代方法以降低发病率。在本综述中，我们讨论前哨淋巴结 mapping 在 EC 手术管理中的作用，评估该手术的各个方面。
