Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy.
Department of Obstetrics and Gynecology, Istituto per la Sicurezza Sociale, 47893, Cailungo-Borgo Maggiore, Republic of San Marino.
Arch Gynecol Obstet. 2019 Feb;299(2):299-315. doi: 10.1007/s00404-018-5006-z. Epub 2018 Dec 12.
Gynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives.
We searched MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS and Grey literature (Google Scholar; British Library) from January 1952 to May 2017, using the terms "ovarian cancer", "endometrial cancer", "cervical cancer", "gynecological cancers" combined with 'elderly', 'cancer', 'clinical trial' and 'geriatric assessment'.
The search identified 81 citations, of which 65 were potentially relevant after initial evaluation and met the criteria for inclusion and were analyzed. We divided all included studies into three different issue: "Endometrial cancer", "Ovarian cancer" and "Cervical cancer".
The present literature review shows that, in spite of the higher burden of comorbidities, elderly patients can also benefit from standard treatment to manage their gynecological cancers. It is important to overcome the common habit of undertreating the elderly patients because they are more fragile and with a lower life expectancy than their younger counterpart. Further trials with elderly women are warranted.
老年人妇科癌症的管理是当前面临的挑战。因此,在目前的研究中,我们旨在收集文献中所有关于老年人妇科癌症的证据,阐述该领域的现状和未来展望。
我们检索了 MEDLINE(PubMed)、EMBASE、Cochrane 中央对照试验注册库、IBECS、BIOSIS、Web of Science、SCOPUS 和灰色文献(Google Scholar;大英图书馆),检索时间从 1952 年 1 月到 2017 年 5 月,使用的术语有“卵巢癌”、“子宫内膜癌”、“宫颈癌”、“妇科癌症”,并结合“老年人”、“癌症”、“临床试验”和“老年评估”。
搜索共确定了 81 条引用,其中 65 条在初步评估后具有潜在相关性,并符合纳入标准进行分析。我们将所有纳入的研究分为三个不同的问题:“子宫内膜癌”、“卵巢癌”和“宫颈癌”。
本文献综述表明,尽管老年人合并症负担较高,但他们也可以从标准治疗中获益,以治疗其妇科癌症。克服对老年患者治疗不足的常见习惯非常重要,因为他们比年轻患者更脆弱,预期寿命更低。有必要对老年女性进行进一步的试验。