Wolff J, Carl P, Crawford M E
Anaesthesia. 1986 Jan;41(1):76-9. doi: 10.1111/j.1365-2044.1986.tb12710.x.
In a double-blind controlled study, epidural buprenorphine 0.3 mg was compared with 4 mg of epidural morphine for postoperative pain relief the first 24 hours after major orthopaedic surgery. The degree of analgesia was equal and satisfactory in both groups. Duration of action was 620 minutes with buprenorphine and 580 minutes with morphine, which was not significantly different. The only serious side effects were recorded in the morphine group, with two patients complaining of pruritus and five of urinary retention. In conclusion, epidural buprenorphine did not offer any advantages in preference to morphine for postoperative pain relief following orthopaedic surgery.
在一项双盲对照研究中，对0.3毫克硬膜外丁丙诺啡与4毫克硬膜外吗啡用于骨科大手术后最初24小时的术后疼痛缓解效果进行了比较。两组的镇痛程度相当且令人满意。丁丙诺啡的作用持续时间为620分钟，吗啡为580分钟，两者无显著差异。仅在吗啡组记录到严重副作用，两名患者出现瘙痒，五名患者出现尿潴留。总之，在骨科手术后的术后疼痛缓解方面，硬膜外丁丙诺啡相对于吗啡并无任何优势。
