线粒体细胞色素c氧化酶基因多态性作为胃癌危险因素的鉴定。
Identification of polymorphisms in mitochondrial cytochrome c oxidase genes as risk factors for gastric cancer.
作者信息
Wang Yingnan, Wang Hongcai, Yin Shice, Zhang Jingjing, Zhang Ruixing, Guo Zhanjun
机构信息
Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Intensive-care Unit, The Xingtai People's Hospital, Xingtai, China.
出版信息
Transl Cancer Res. 2020 Jun;9(6):3854-3859. doi: 10.21037/tcr-19-2227.
BACKGROUND
Single nucleotide polymorphisms (SNPs) in the D-Loop region of mitochondrial DNA (mtDNA) have been implied in tumorigenesis of different types of tumors, but the associations involving polymorphisms in mtDNA coding regions still need to be clarified. This study aimed to identify SNPs of mitochondrial cytochrome c oxidase genes (MT-CO) in the occurrence of gastric cancer (GC).
METHODS
The MT-CO genes were sequenced between 170 GC patients and 174 matched healthy controls. The test was used to analyze differences in SNP frequencies between the two groups.
RESULTS
The SNPs of MT-CO region were associated with the risk of GC. The genotype 9540T was significantly associated with an increased risk for GC (P=0.018), whereas 9548G was associated with a reduced risk (P=0.029).
CONCLUSIONS
The SNPs in MT-CO genes were found to be risk biomarkers for GC. It may provide a novel insight into the molecular mechanism in GC tumorigenesis and progression.
背景
线粒体DNA（mtDNA）D环区域的单核苷酸多态性（SNP）已被认为与不同类型肿瘤的发生有关，但mtDNA编码区域多态性的相关情况仍有待阐明。本研究旨在确定线粒体细胞色素c氧化酶基因（MT-CO）的SNP在胃癌（GC）发生中的作用。
方法
对170例GC患者和174例匹配的健康对照者的MT-CO基因进行测序。采用检验分析两组间SNP频率的差异。
结果
MT-CO区域的SNP与GC风险相关。基因型9540T与GC风险增加显著相关（P=0.018），而9548G与风险降低相关（P=0.029）。
结论
发现MT-CO基因中的SNP是GC的风险生物标志物。这可能为GC发生和发展的分子机制提供新的见解。
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