Ji Bingzhou, Yang Guang, Jin Hongfu, Liu Xu, Li Hengzhen, Pan Linyuan, Lu Wenhao, Zhu Heyuan, Li Yusheng
Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Orthopedics, Central Hospital of Loudi, Loudi, Hunan, China.
Heliyon. 2023 Aug 7;9(8):e18950. doi: 10.1016/j.heliyon.2023.e18950. eCollection 2023 Aug.
Ferroptosis was proposed to be a type of programmed cell death in 2012. Ferroptosis plays a significant role in a variety of illnesses.
To better understand the direction of future research, we performed a bibliometric analysis to identify research hotspots with a focus on ferroptosis.
The search terms [TI = "ferroptosis" OR ("GSH" AND "GPX4") OR "lipid peroxidation" OR "iron homeostasis" OR "iron metabolism"] AND [PY = "2012-2022"] AND [DT = "Article OR Review"] AND [LA = "English"] were used to retrieve publications related to ferroptosis for a bibliometric analysis. We utilized Microsoft Excel to calculate the frequency and proportion of the published articles, VOSviewer to perform a co-occurrence analysis and for visualizing the data, CiteSpace to obtain a timeline of keywords and institutions, and RStudio to calculate citation metrics. As indicated by the analysis, indicators such as the number of publications, the most productive authors and coauthorship status, the distribution of publications by country, favoured journals, the most influential institutions and the most frequently cited documents are reported in this article.
A total of 8009 publications were retrieved from the WOS core collection, and 197 papers published in 2023 were removed from this analysis. The remaining 7812 papers, which included 118 in the WOS collection, were incorporated into the bibliometric study.
The number of annual scientific publications on ferroptosis have been increasing each year. The academic communities represented by Tang, Daolin, Stockwell, Brent R., Wang, Fudi, and Conrad, Marcus were the most authoritative. China, USA, and Germany were the front-runners in the field of ferroptosis. was the largest contributor of ferroptosis-related research, and and were the most influential journals to publish articles on ferroptosis. Columbia Univ and Univ Pittsburgh were the institutions that received the most attention. Recent research on ferroptosis has been focused on molecular mechanisms, particularly those in the contexts of various diseases, which will be a hotspot of future research. In addition, interdisciplinary ferroptosis and big-data research is expected to be a new frontier.
2012年，铁死亡被提出是一种程序性细胞死亡。铁死亡在多种疾病中发挥着重要作用。
为了更好地了解未来的研究方向，我们进行了文献计量分析，以确定铁死亡相关的研究热点。
检索词[标题=“铁死亡”或（“谷胱甘肽”和“谷胱甘肽过氧化物酶4”）或“脂质过氧化”或“铁稳态”或“铁代谢”]且[出版年份=“2012 - 2022”]且[文献类型=“文章或综述”]且[语言=“英语”]用于检索与铁死亡相关的出版物以进行文献计量分析。我们使用Microsoft Excel计算已发表文章的频率和比例，使用VOSviewer进行共现分析并可视化数据，使用CiteSpace获取关键词和机构的时间线，使用RStudio计算引用指标。分析表明，本文报告了诸如出版物数量、最高产作者和共同作者状态、按国家划分的出版物分布、青睐的期刊、最具影响力的机构以及被引用最多的文献等指标。
从WOS核心合集中检索到8009篇出版物，本分析剔除了2023年发表的197篇论文。其余7812篇论文（包括WOS合集中的118篇）被纳入文献计量研究。
每年关于铁死亡的科学出版物数量一直在增加。以唐道林、斯托克韦尔、布伦特·R·王、傅迪和马库斯·康拉德为代表的学术团体最具权威性。中国、美国和德国在铁死亡领域处于领先地位。 是铁死亡相关研究的最大贡献者， 和 是发表铁死亡相关文章最具影响力的期刊。哥伦比亚大学和匹兹堡大学是最受关注的机构。最近关于铁死亡的研究集中在分子机制上，特别是在各种疾病背景下的分子机制，这将是未来研究的一个热点。此外，铁死亡的跨学科和大数据研究有望成为一个新的前沿领域。
