系统性红斑狼疮患者外周血中人类B细胞集落的生长
Growth of human B cell colonies from peripheral blood of patients with systemic lupus erythematosus.
作者信息
Fay A C, Price S, Trudgett A, McCrea J D, Haire M, Boyd M W, McNeill T A
出版信息
Ann Rheum Dis. 1986 Feb;45(2):95-100. doi: 10.1136/ard.45.2.95.
Abstract
Human B cell colonies were grown from peripheral blood of 12 patients with systemic lupus erythematosus (SLE) and from 12 healthy control subjects. The SLE group showed a large increase (p less than 0.001) in the number of colony forming cells (CFC) present in peripheral blood as compared with controls. The CFC were of the pre-B cell type. There was also a loss of OKT8+ cell inhibition of B cell colony growth in the SLE group compared with control subjects.
摘要
从12例系统性红斑狼疮（SLE）患者及12名健康对照者的外周血中培养出人类B细胞集落。与对照组相比，SLE组外周血中集落形成细胞（CFC）数量大幅增加（p<0.001）。这些CFC属于前B细胞类型。与对照受试者相比，SLE组中B细胞集落生长的OKT8 +细胞抑制作用也有所丧失。
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