Calderon R A, Thomas D B
Nature. 1980 Jun 26;285(5767):662-4. doi: 10.1038/285662a0.
The humoral response to hapten-protein conjugates is an invaluable model for dissecting the cellular elements of lymphocyte cooperation, and the Mitchison secondary adoptive transfer system provides convincing evidence of cooperation between hapten-specific B cells and carrier-specific T cells in the production of anti-hapten antibody. Recently, attention has focused on the role of suppressor T cells in the regulation of antibody production. Several workers have shown that carrier-priming may, in some instances, suppress a subsequent hapten antibody response, both in vivo and in vitro. This effect is attributed to a suppressor T-cell population, generated during the initial phase of the immune response. Gershon and co-workers have postulated that such suppressor T cells function in a feedback regulatory loop to limit the duration of an immune response. We have examined the suppressive effect of carrier immunization in a secondary anti-hapten response in vivo and demonstrate a cyclic change in susceptibility of memory B cells to T-help and suppression. Such variation presents a severe restriction to any model of feedback control by suppressor T cells.
对半抗原-蛋白质偶联物的体液免疫反应是剖析淋巴细胞协作细胞成分的一个非常有价值的模型，并且米奇森二次继代移植系统为半抗原特异性B细胞与载体特异性T细胞在抗半抗原抗体产生过程中的协作提供了令人信服的证据。最近，注意力集中在了抑制性T细胞在抗体产生调节中的作用上。几位研究者已表明，在某些情况下，载体致敏在体内和体外均可能抑制随后的半抗原抗体反应。这种效应归因于在免疫反应初始阶段产生的一群抑制性T细胞。格申及其同事推测，此类抑制性T细胞在一个反馈调节环路中发挥作用，以限制免疫反应的持续时间。我们已在体内二次抗半抗原反应中检测了载体免疫的抑制效应，并证明记忆B细胞对T辅助和抑制的易感性呈周期性变化。这种变化对抑制性T细胞的任何反馈控制模型都构成了严重限制。
