South African Medical Research Council/Cape Peninsula University of Technology Cardio-metabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa.
Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé 1, Yaoundé, Cameroon.
Medicine (Baltimore). 2022 Feb 4;101(5):e28642. doi: 10.1097/MD.0000000000028642.
Leukocyte Telomere length (LTL) is an independent predictor of cardio-metabolic diseases (CMDs) and Human Immuno Virus (HIV) infection. However, studies are lacking on the association between LTL with CMD profile in people with HIV. Accordingly, we investigated the association between LTL and CMD profile in HIV-infected adult South Africans.This cross-sectional study included 728 HIV patients (20.6% men; median age 38 years) recruited across 17 public healthcare facilities in Cape Town. CMD markers were compared across quartiles of LTL, and spearman correlations assessed the continuous association of LTL with CMD markers. Linear and logistic regressions were then used to relate LTL with CMD risk profile, with appropriate adjustment for confounders.The prevalence of obesity, hypertension and diabetes were 34.8%, 36.8%, and 8.4%, respectively. In age, sex and body mass index adjusted models, increasing Log10LTL was associated with decreasing systolic (β = -10.52) and diastolic (β = -6.74) blood pressures, HOMA-β (β = -70.72), increasing total cholesterol (β = 0.544), non-high-density lipoprotein cholesterol (β = 0.472), and waist-to-height-ratio > 0.5 (odds ratio [OR] = 5.67), all P < .05. Compared to those in the bottom quarter, those in the top LTL quarter had lower prevalence of hypertension (OR = 0.65), and higher prevalence of total cholesterol > 5 mmol/L (OR = 1.94), and low-density lipoprotein-cholesterol > 3 mmol/L (OR = 1.62), all P < .05. LTL was not associated with diabetes nor general obesity. It was associated with Alanine Transaminase (ALT) and heart rate in univariable analyses.LTL shortening was associated with some CMD risk factors in HIV-infected adults on anti-retroviral therapy in South Africa. Prospective research is needed to explore the direction and implications of these associations.
白细胞端粒长度 (LTL) 是心血管代谢疾病 (CMD) 和人类免疫缺陷病毒 (HIV) 感染的独立预测因子。然而，关于 HIV 感染者中 LTL 与 CMD 特征之间的关联的研究尚缺乏。因此，我们调查了南非 HIV 感染者中 LTL 与 CMD 特征之间的关联。
这项横断面研究纳入了来自开普敦 17 家公共医疗保健机构的 728 名 HIV 患者（20.6%为男性；中位年龄 38 岁）。根据 LTL 的四分位数比较了 CMD 标志物，Spearman 相关性评估了 LTL 与 CMD 标志物的连续相关性。然后使用线性和逻辑回归来研究 LTL 与 CMD 风险特征的关系，并适当调整混杂因素。
肥胖、高血压和糖尿病的患病率分别为 34.8%、36.8%和 8.4%。在年龄、性别和体重指数调整模型中，Log10LTL 的增加与收缩压（β=-10.52）和舒张压（β=-6.74）的降低、HOMA-β（β=-70.72）、总胆固醇（β=0.544）、非高密度脂蛋白胆固醇（β=0.472）和腰高比>0.5（比值比 [OR]=5.67）的升高相关，所有 P<.05。与处于 LTL 最低四分位的患者相比，处于 LTL 最高四分位的患者高血压的患病率较低（OR=0.65），总胆固醇>5 mmol/L（OR=1.94）和低密度脂蛋白胆固醇>3 mmol/L（OR=1.62）的患病率较高，所有 P<.05。LTL 与糖尿病或普通肥胖无关。在单变量分析中，LTL 与丙氨酸转氨酶 (ALT) 和心率相关。
在南非接受抗逆转录病毒治疗的 HIV 感染者中，LTL 缩短与一些 CMD 危险因素相关。需要进行前瞻性研究来探索这些关联的方向和意义。
