Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé 1, Yaoundé, Cameroon.
South African Medical Research Council/Cape Peninsula University of Technology Cardio-Metabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa.
Sci Rep. 2022 Feb 28;12(1):3323. doi: 10.1038/s41598-022-07328-8.
Several studies have reported a possible association between leucocyte telomere length (LTL) and cardio-metabolic diseases (CMDs). However, studies investigating such association are lacking in South Africa despite having a very high prevalence of CMDs. We investigated the association between LTL and CMD risk profile in a black South African population. This was a cross-sectional study with participants > 21 years of age and residing in five townships in Cape Town. CMD markers were compared between men and women and across quartiles of LTL. Linear and logistic regressions relate increasing quartile and LogLTL with CMD risk profile, with appropriate adjustment. Among 676-participants, diabetes, obesity and hypertension prevalence were 11.5%, 23.1% and 47.5%. Waist-circumference, hip-circumference and highly sensitive c-reactive protein values were significantly higher in women (all p < 0.001), while HDL-C (p = 0.023), creatinine (p = 0.005) and gamma glutamyl transferase (p < 0.001) values were higher in men. In age, sex and BMI adjusted linear regression model, Log of LTL was associated with low HDL-C (beta = 0.221; p = 0.041) while logistic regression showed a significant association between LogLTL and prevalent dyslipidaemia characterised by high LDL-C. In this population, the relationship between LTL and CMD is weak given its association with only HDL-C and LDL-C.
几项研究报告称，白细胞端粒长度 (LTL) 与心血管代谢疾病 (CMDs) 之间可能存在关联。然而，尽管南非 CMDs 的患病率非常高，但缺乏对此类关联的研究。我们调查了 LTL 与南非黑人人群 CMD 风险特征之间的关系。这是一项横断面研究，参与者年龄在 21 岁以上，居住在开普敦的五个城镇。比较了男性和女性以及 LTL 四分位区间的 CMD 标志物。线性和逻辑回归将 quartile 和 LogLTL 与 CMD 风险特征相关联，并进行适当调整。在 676 名参与者中，糖尿病、肥胖和高血压的患病率分别为 11.5%、23.1%和 47.5%。女性的腰围、臀围和高敏 C 反应蛋白值显著更高（均 p<0.001），而男性的 HDL-C（p=0.023）、肌酐（p=0.005）和γ谷氨酰转移酶（p<0.001）值更高。在年龄、性别和 BMI 调整的线性回归模型中，LTL 的对数与低 HDL-C 相关（beta=0.221；p=0.041），而逻辑回归显示 LogLTL 与以高 LDL-C 为特征的常见血脂异常之间存在显著关联。在该人群中，由于 LTL 仅与 HDL-C 和 LDL-C 相关，因此与 CMD 之间的关系较弱。
