Wang Chi-Cha, Wei Shu-Chen, Luo Shyh-Chyang
Department of Materials Science and Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, No.1 Jen Ai Road, Section 1, Taipei 10051, Taiwan.
ACS Appl Bio Mater. 2022 May 16;5(5):1916-1933. doi: 10.1021/acsabm.1c01194. Epub 2022 Feb 4.
Conducting polymers (CPs) are of great interests to researchers around the world in biomedical applications owing to their unique electrical and mechanical properties. Besides, they are easy to fabricate and have long-term stability. These features make CPs a powerful building block of modern biomaterials. Peptide functionalization has been a versatile tool for the development of CP-based biomaterials. With the aid of peptide modifications, the biocompatibility, target selectivity, and cellular interactions of CPs can be greatly improved. Reflecting these aspects, an increasing number of studies on peptide-integrated conducting polymers have been reported recently. In this review, various kinds of peptide immobilization strategies on CPs are introduced. Moreover, the aims of peptide modification are discussed in three aspects: enhancing the specific selectivity, avoiding nonspecific adhesion, and mimicking the environment of extracellular matrix. We highlighted recent studies in the applications of peptide-integrated CPs in electrochemical sensors, antifouling surfaces, and conductive biointerfaces. These studies have shown great potentials from the integration of peptide and CPs as a versatile platform for advanced biological and clinical applications in the near future.
导电聚合物（CPs）因其独特的电学和力学性能，在生物医学应用方面引起了全球研究人员的极大兴趣。此外，它们易于制备且具有长期稳定性。这些特性使导电聚合物成为现代生物材料的强大组成部分。肽功能化一直是开发基于导电聚合物的生物材料的通用工具。借助肽修饰，导电聚合物的生物相容性、靶向选择性和细胞相互作用可得到极大改善。反映在这些方面，最近报道了越来越多关于肽整合导电聚合物的研究。在这篇综述中，介绍了在导电聚合物上的各种肽固定策略。此外，从增强特异性选择性、避免非特异性粘附以及模拟细胞外基质环境这三个方面讨论了肽修饰的目的。我们重点介绍了肽整合导电聚合物在电化学传感器、防污表面和导电生物界面应用方面的最新研究。这些研究表明，肽与导电聚合物的整合作为一个通用平台，在不久的将来用于先进的生物和临床应用具有巨大潜力。
