McLennan F M, Haites N E, Mackenzie J D, Daniel M K, Rawles J M
Br Heart J. 1986 Jan;55(1):25-31. doi: 10.1136/hrt.55.1.25.
Inclusion of a pig aorta in an artificial circulation with pulsed blood flow allowed correlation of minute distance, measured in the aorta by Doppler ultrasound, and absolute blood flow, measured by timed blood-volume collection. The correlation coefficient was 0.99 with a standard error of prediction that was 5.4% of the minute distance predicted at a standard flow rate of 5 litres per minute. The horizontal distance between 95% confidence limits for a single prediction expressed as a percentage of 5 litres per minute was 33%, and this corresponded to the range of flow rates of 1.65 litres per minute that could give rise to the same measurement. In 142 patients duplicate measurements of minute distance were made with repositioning of the ultrasound transducer between recordings. The mean difference between paired readings, expressed as a percentage of the average (SD) of each pair was 5.4 (4.7)%. Thus, the non-invasive measurement of linear cardiac output by Doppler ultrasound is similarly reproducible in vitro and in vivo and compares favourably with the measurement of volumetric cardiac output by thermodilution.
将猪主动脉纳入具有脉冲血流的人工循环中，可使通过多普勒超声在主动脉中测量的微小距离与通过定时血容量收集测量的绝对血流相关联。相关系数为0.99，预测标准误差为每分钟5升标准流速下预测微小距离的5.4%。单个预测的95%置信限之间的水平距离以每分钟5升的百分比表示为33%，这对应于可能产生相同测量结果的1.65升/分钟的流速范围。在142例患者中，在记录之间重新定位超声换能器对微小距离进行了重复测量。配对读数之间的平均差异，以每对平均值（标准差）的百分比表示为5.4（4.7）%。因此，多普勒超声对线性心输出量的无创测量在体外和体内具有相似的可重复性，与热稀释法测量容量性心输出量相比具有优势。
