肝脏微粒体酶诱导剂和抑制剂对人体胰岛素介导的葡萄糖代谢的影响。
The effect of liver microsomal enzyme inducing and inhibiting drugs on insulin mediated glucose metabolism in man.
作者信息
Lahtela J T, Gachalyi B, Eksymä S, Hämäläinen A, Sotaniemi E A
出版信息
Br J Clin Pharmacol. 1986 Jan;21(1):19-26. doi: 10.1111/j.1365-2125.1986.tb02818.x.
The effects of hepatic microsomal enzyme inducing (phenobarbitone and flumecinol), and inhibiting (cimetidine) drugs, and placebo treatment on insulin mediated glucose metabolism (M) were investigated in 29 healthy volunteers. Phenobarbitone (50 mg for 10 days) increased M (30%), metabolic clearance rate of glucose (MCRg), and antipyrine clearance rate (33%). Fasting immunoreactive insulin (IRI) decreased while fasting blood glucose (BG) remained unaltered. Flumecinol, another inducer, tested in two doses (200 mg and 600 mg for 6 days), did not alter glucose or antipyrine metabolism. Fasting IRI reduced on treatment with 600 mg of flumecinol, but not with the smaller dose. Cimetidine (600 mg for 6 days) decreased M (19.5%), MCRg (26%), and antipyrine clearance rate (20%). The placebo did not alter glucose or antipyrine metabolism. The results indicate that the insulin mediated glucose disposal rate can be altered by drugs influencing hepatic microsomal enzyme activity.
在29名健康志愿者中研究了肝微粒体酶诱导剂（苯巴比妥和氟甲西诺）、抑制剂（西咪替丁）以及安慰剂治疗对胰岛素介导的葡萄糖代谢（M）的影响。苯巴比妥（50毫克，服用10天）使M增加（30%）、葡萄糖代谢清除率（MCRg）以及安替比林清除率增加（33%）。空腹免疫反应性胰岛素（IRI）降低，而空腹血糖（BG）保持不变。另一种诱导剂氟甲西诺以两种剂量（200毫克和600毫克，服用6天）进行测试，未改变葡萄糖或安替比林代谢。用600毫克氟甲西诺治疗时空腹IRI降低，但较小剂量时未降低。西咪替丁（600毫克，服用6天）使M降低（19.5%）、MCRg降低（26%）以及安替比林清除率降低（20%）。安慰剂未改变葡萄糖或安替比林代谢。结果表明，影响肝微粒体酶活性的药物可改变胰岛素介导的葡萄糖处置率。
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