慢性口服西咪替丁对人体肝脏表观血流量及肝微粒体酶活性的影响。
Effects of chronic oral cimetidine on apparent liver blood flow and hepatic microsomal enzyme activity in man.
作者信息
Daneshmend T K, Ene M D, Parker G, Roberts C J
出版信息
Gut. 1984 Feb;25(2):125-8. doi: 10.1136/gut.25.2.125.
Abstract
Cimetidine 200 mg three times daily and 400 mg at night was given to 10 subjects for four weeks. Apparent liver blood flow was measured by indocyanine green clearance and microsomal enzyme activity by antipyrine clearance, before and after cimetidine. There was no reduction in indocyanine green clearance but antipyrine clearance, as expected, was significantly reduced by 15% at four weeks. Chronic cimetidine treatment does not reduce apparent liver blood flow and is therefore unlikely to be of use in the treatment of portal hypertension. The cimetidine associated hepatic enzyme inhibition appears to persist with prolonged treatment. Therefore patients on chronic cimetidine remain vulnerable to certain drug interactions.
摘要
给10名受试者每日3次服用200毫克西咪替丁，夜间服用400毫克，持续四周。在服用西咪替丁前后，通过吲哚菁绿清除率测量表观肝血流量，通过安替比林清除率测量微粒体酶活性。吲哚菁绿清除率没有降低，但正如预期的那样，四周时安替比林清除率显著降低了15%。长期服用西咪替丁不会降低表观肝血流量，因此不太可能用于治疗门静脉高压症。西咪替丁相关的肝酶抑制作用似乎会随着长期治疗而持续存在。因此，长期服用西咪替丁的患者仍易发生某些药物相互作用。
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