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[α-半乳糖综合征：临床表现与病理生理学概述]

[Alpha-gal syndrome : Overview of clinical presentation and pathophysiology].

作者信息

Fischer J, Reepschläger T, Schricker T, Raap U

机构信息

Universitätsklinik für Dermatologie und Allergologie, Klinikum Oldenburg AöR und Abteilung für experimentelle Allergologie und Immundermatologie, Carl von Ossietzky Universität Oldenburg, Rahel-Straus-Str. 10, 26133, Oldenburg, Deutschland.

Universitäts-Hautklinik, Universitätsklinik Tübingen, Eberhard Karls Universität Tübingen, Tübingen, Deutschland.

出版信息

Hautarzt. 2022 Mar;73(3):195-200. doi: 10.1007/s00105-022-04943-4. Epub 2022 Feb 4.

DOI:10.1007/s00105-022-04943-4
PMID:35119482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8815393/
Abstract

In the world of allergology, alpha-gal syndrome remains one of the most fascinating discoveries over the last 15 years as it is triggered by specific IgE directed against the immunogenic sugar galactose-α‑1,3‑galactose (alpha-gal), found foremost in mammalian meat, milk and products derived thereof, potentially resulting in anaphylaxis. Also, mammalian-derived drugs and medical products have been identified as possible culprits. Nonetheless, tick bites remain the major cause of specific alpha-gal-sIgE. Herein, we summarize the current clinical knowledge and pathophysiology of alpha-gal syndrome in order to better understand this disease.

摘要

在过敏反应学领域，α-半乳糖综合征仍然是过去15年中最引人入胜的发现之一，因为它是由针对免疫原性糖半乳糖-α-1,3-半乳糖（α-半乳糖）的特异性IgE引发的，这种糖主要存在于哺乳动物的肉、奶及其衍生产品中，可能导致过敏反应。此外，源自哺乳动物的药物和医疗产品也被确定为可能的罪魁祸首。尽管如此，蜱虫叮咬仍然是特异性α-半乳糖-sIgE的主要原因。在此，我们总结了α-半乳糖综合征的当前临床知识和病理生理学，以便更好地了解这种疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/8815393/6e04670ffafb/105_2022_4943_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/8815393/78bf191e8d59/105_2022_4943_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/8815393/18793049e41d/105_2022_4943_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/8815393/c475320cd0fb/105_2022_4943_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/8815393/6e04670ffafb/105_2022_4943_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/8815393/78bf191e8d59/105_2022_4943_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/8815393/18793049e41d/105_2022_4943_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/8815393/c475320cd0fb/105_2022_4943_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79c7/8815393/6e04670ffafb/105_2022_4943_Fig4_HTML.jpg

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本文引用的文献

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Clin Exp Allergy. 2022 Jan;52(1):197-200. doi: 10.1111/cea.14054. Epub 2021 Nov 24.
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Allergic response to medical products in patients with alpha-gal syndrome.α-半乳糖综合征患者对医用产品的过敏反应。
J Thorac Cardiovasc Surg. 2022 Dec;164(6):e411-e424. doi: 10.1016/j.jtcvs.2021.03.100. Epub 2021 Apr 9.
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Gelatin-Containing Vaccines for Varicella, Zoster, Measles, Mumps, and Rubella Induce Basophil Activation in Patients with Alpha-Gal Syndrome.
Cureus. 2022 Jun 26;14(6):e26351. doi: 10.7759/cureus.26351. eCollection 2022 Jun.
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Current and Future Strategies for the Diagnosis and Treatment of the Alpha-Gal Syndrome (AGS).α-半乳糖综合征（AGS）诊断与治疗的当前及未来策略
J Asthma Allergy. 2022 Jul 18;15:957-970. doi: 10.2147/JAA.S265660. eCollection 2022.
含明胶的水痘、带状疱疹、麻疹、腮腺炎和风疹疫苗可诱导α-半乳糖综合征患者的嗜碱性粒细胞活化。
Int Arch Allergy Immunol. 2021;182(8):716-722. doi: 10.1159/000514263. Epub 2021 Mar 18.
4
The History of Carbohydrates in Type I Allergy.碳水化合物在 I 型过敏中的历史。
Front Immunol. 2020 Oct 9;11:586924. doi: 10.3389/fimmu.2020.586924. eCollection 2020.
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IgE autoantibodies in serum and skin of non-bullous and bullous pemphigoid patients.非大疱性类天疱疮和大疱性类天疱疮患者血清及皮肤中的IgE自身抗体。
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