Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China.
Central Research Institute, United Imaging Healthcare, Shanghai, China.
J Magn Reson Imaging. 2022 Oct;56(4):1009-1017. doi: 10.1002/jmri.28097. Epub 2022 Feb 4.
Recently, a prototype 5.0 T whole-body MRI scanner was developed. A 5.0 T diffusion-weighted imaging (DWI) may help overcome the issues that limit 3.0 T DWI.
To evaluate the feasibility of 5.0 T high-field DWI in the upper abdomen and assess the agreement of the apparent diffusion coefficient (ADC) with that from 3.0 T abdominal DWI.
Prospective proof of concept.
Nine volunteers (mean ± SD age: 37.3 ± 7.0 years, 8 M), eight healthy and one with liver and kidney cysts.
FIELD STRENGTH/SEQUENCE: 3.0 T and 5.0 T; respiratory-triggered spin-echo echo-planar-imaging (SE-EPI)-based DWI sequence.
Subjective image quality scores. The ADC values in abdominal organs (liver, pancreas, spleen, and kidney) were measured by two observers for evaluating the interobserver and interfield agreement.
Wilcoxon-rank sum test, Bland-Altman analysis, intraclass correlation coefficients (ICCs), and coefficients of variation (CVs).
The 5.0 T DWI displayed an increase in subjective image quality score compared to 3.0 T DWI without the significant difference (3.0 T DWI: 3.50 ± 0.47, 5.0 T DWI: 3.72 ± 0.42, P = 0.157). Both the interfield and interobserver agreements of ADC values were substantial to excellent (ICCs = 0.640-0.902). For all four upper abdominal organs, there were no significant differences between the ADC values measured by two observers and between the ADC values of 3.0 T and 5.0 T DWI (P = 0.134-1.000). The CVs of ADC measurements from 3.0 T and 5.0 T DWI were all less than 15.0% (6.7%-14.2%).
The substantial to excellent agreements between the ADC values measured with 3.0 T and 5.0 T DWI for liver, pancreas, spleen, and kidney suggested that 5.0 T DWI can be applied for abdominal imaging. The ADC values from 5.0 T abdominal DWI hold the potential to serve as the quantitative markers for clinical investigations.
2 TECHNICAL EFFICACY: Stage 1.
最近开发了一款原型 5.0T 全身磁共振成像扫描仪。5.0T 扩散加权成像（DWI）可能有助于克服限制 3.0T DWI 的问题。
评估 5.0T 高场 DWI 在腹部上部的可行性，并评估表观扩散系数（ADC）与 3.0T 腹部 DWI 的一致性。
前瞻性概念验证。
9 名志愿者（平均年龄±标准差：37.3±7.0 岁，8 名男性），8 名健康志愿者和 1 名肝、肾囊肿患者。
磁场强度/序列：3.0T 和 5.0T；呼吸触发的自旋回波回波平面成像（SE-EPI）DWI 序列。
主观图像质量评分。由两名观察者测量腹部器官（肝、胰腺、脾和肾）的 ADC 值，以评估观察者间和场间的一致性。
Wilcoxon 秩和检验、Bland-Altman 分析、组内相关系数（ICC）和变异系数（CV）。
与 3.0T DWI 相比，5.0T DWI 的主观图像质量评分有所提高，但差异无统计学意义（3.0T DWI：3.50±0.47，5.0T DWI：3.72±0.42，P=0.157）。ADC 值的场间和观察者间一致性均为中等至极好（ICC=0.640-0.902）。对于所有四个上腹部器官，两名观察者测量的 ADC 值之间以及 3.0T 和 5.0T DWI 的 ADC 值之间均无显著差异（P=0.134-1.000）。3.0T 和 5.0T DWI 的 ADC 测量值的 CV 均小于 15.0%（6.7%-14.2%）。
3.0T 和 5.0T DWI 测量的肝、胰腺、脾和肾的 ADC 值之间具有中等至极好的一致性，表明 5.0T DWI 可用于腹部成像。5.0T 腹部 DWI 的 ADC 值有可能成为临床研究的定量标志物。
2 技术功效：阶段 1。
