Department of Neurology, National Hospital of Niamey, PO Box 238, Niamey, Niger.
Department of Medicine and Medical Specialties, Regional Hospital Center of Dosso, Dosso, Niger.
BMC Neurol. 2022 Feb 4;22(1):44. doi: 10.1186/s12883-022-02569-6.
The usual neurologic manifestations of Vogt-Koyanagi-Harada (VKH) disease include aseptic meningitis and headaches. We performed the present study to review all unusual neurologic manifestations reported in VKH disease to summarize them.
A literature search was performed in the English language on Scopus and Medline via PubMed from 1946 to July 31, 2021, by using the following terms: "Vogt Koyanagi Harada disease" OR "VKH disease" AND "Brain" OR "Spinal cord" OR "CNS" OR "Central nervous system" OR "Neurologic" OR "Peripheral nervous system" OR "Polyneuropathies. Our inclusion criteria were unusual neurologic manifestations of VKH disease.
Our literature search yielded 417 total articles (PubMed = 334, Scopus = 83) from which 32 studies comprising 43 patients (22 men and 21 women, of which 62.8% were younger than 50 years) were included in this systematic literature review. Regarding the study design, all studies were case reports and published between 1981 and 2021. CNS involvement was the most reported (93%) in VKH disease. Peripheral nervous system involvement represents 7% of cases. The cerebral lesions were parenchymal inflammatory lesions in the white matter or posterior fossa with or no contrast enhancement (16.3%), leptomeningitis (9.3%), pachymeningitis (7%), meningoencephalitis (2.3%), ischemic stroke (4.6%), hemorrhagic stroke (2.3%), transient ischemic attack (2.3%), and hydrocephalus (2.3%). The optic nerve lesions were anterior ischemic optic neuropathy (20.9%) and optic neuritis (9.3%). Concerning spinal cord lesion, it was mainly myelitis (14%).
This systematic literature review provides a summary of the different unusual neurologic manifestations reported in VKH disease.
Vogt-小柳原田（Vogt-Koyanagi-Harada，VKH）病的常见神经系统表现包括无菌性脑膜炎和头痛。我们进行了本研究，以回顾 VKH 病中报告的所有不常见的神经系统表现，并对其进行总结。
我们在 Scopus 和 Medline 上通过 PubMed 以英语进行了文献检索，检索时间从 1946 年至 2021 年 7 月 31 日，使用了以下术语：“Vogt-Koyanagi-Harada 病”或“VKH 病”以及“脑”或“脊髓”或“中枢神经系统”或“神经系统”或“周围神经系统”或“多发性神经病”。我们的纳入标准是 VKH 病的不常见神经系统表现。
我们的文献检索共得到 417 篇文章（PubMed=334，Scopus=83），其中 32 项研究共纳入 43 例患者（22 名男性和 21 名女性，其中 62.8%年龄小于 50 岁）纳入本系统综述。关于研究设计，所有研究均为病例报告，发表于 1981 年至 2021 年之间。中枢神经系统受累是 VKH 病中最常见的表现（93%）。周围神经系统受累占病例的 7%。脑部病变为白质或后颅窝的实质炎症性病变，伴或不伴对比增强（16.3%）、脑膜炎（9.3%）、脑脊髓膜炎（7%）、脑膜脑炎（2.3%）、缺血性脑卒中（4.6%）、出血性脑卒中（2.3%）、短暂性脑缺血发作（2.3%）和脑积水（2.3%）。视神经病变为前部缺血性视神经病变（20.9%）和视神经炎（9.3%）。脊髓病变主要为脊髓炎（14%）。
本系统文献综述总结了 VKH 病中报告的不同不常见神经系统表现。
