CÚRAM SFI Research Centre for Medical Devices, National University of Ireland Galway, H92 W2TY, Ireland.
CÚRAM SFI Research Centre for Medical Devices, National University of Ireland Galway, H92 W2TY, Ireland; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan 20126, Italy.
Trends Mol Med. 2022 Apr;28(4):270-289. doi: 10.1016/j.molmed.2022.01.004. Epub 2022 Feb 1.
The importance of glycosylation (post-translational attachment of glycan residues to proteins) in the context of neuroinflammation is only now beginning to be understood. Although the glycome is challenging to investigate due to its complexity, this field is gaining interest because of the emergence of novel analytical methods. These investigations offer the possibility of further understanding the molecular signature of disorders with underlying neuroinflammatory cascades. In this review, we portray the clinically relevant trends in glyconeurobiology and suggest glyco-related paths that could be targeted therapeutically to decrease neuroinflammation. A combinatorial insight from glycobiology and neurology can be harnessed to better understand neuroinflammatory-related conditions to identify relevant molecular targets.
糖基化（聚糖残基在蛋白质上的翻译后附着）在神经炎症背景下的重要性现在才开始被理解。尽管糖组学由于其复杂性而难以研究，但由于出现了新的分析方法，这个领域越来越受到关注。这些研究为进一步了解潜在神经炎症级联反应的疾病的分子特征提供了可能性。在这篇综述中，我们描绘了糖神经生物学中的临床相关趋势，并提出了可能的糖相关途径，以减少神经炎症。糖生物学和神经学的组合见解可以被利用来更好地理解与神经炎症相关的疾病，以确定相关的分子靶点。
