Physiology and Physiopathology Team, Faculty of Sciences, Genomic of Human Pathologies Research, Mohammed V University in Rabat, Morocco; Laboratoire d'Immunologie, Institut National d'Hygiene, Rabat, Morocco.
National Research Council (CNR)-Institute of Translational Pharmacology (IFT), L'Aquila, Italy.
Clin Chim Acta. 2022 Mar 1;528:74-83. doi: 10.1016/j.cca.2022.01.022. Epub 2022 Feb 1.
Celiac disease (CD) is a chronic inflammatory enteropathy caused by gluten (protein from wheat, rye and, barley) in genetically predisposed individuals carrying the HLA-DQ2/HLA-DQ8 genotype. This pathology has a multifactorial etiology in which HLA genes, the microbiome, gluten and, other environmental factors are involved in the development of the disease. Its pathogenesis involves both innate and adaptive immunity as well as upregulation of IL-15. The objective of this review is to examine the results of current studies on genetic and environmental variables to better understand the pathogenesis of this enteropathy. The complex etiology of celiac disease makes our understanding of the pathogenesis of the disease incomplete, and a better knowledge of the many genetic and environmental components would help us better understand the pathophysiology of celiac disease.
乳糜泻（CD）是一种由麸质（小麦、黑麦和大麦中的蛋白质）引起的慢性炎症性肠病，在携带 HLA-DQ2/HLA-DQ8 基因型的遗传易感性个体中发生。这种病理学具有多因素病因，其中 HLA 基因、微生物组、麸质和其他环境因素参与疾病的发展。其发病机制涉及先天和适应性免疫以及 IL-15 的上调。本综述的目的是检查当前关于遗传和环境变量的研究结果，以更好地了解这种肠病的发病机制。乳糜泻的复杂病因使得我们对该病发病机制的理解不完整，对许多遗传和环境因素的更好了解将有助于我们更好地理解乳糜泻的病理生理学。
