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cGAS/STING 信号通路与细胞周期相互作用，增强癌症免疫治疗效果。

cGAS/STING cross-talks with cell cycle and potentiates cancer immunotherapy.

机构信息

Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China; Institute of Hematology, Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China.

Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China; Institute of Hematology, Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China.

出版信息

Mol Ther. 2022 Mar 2;30(3):1006-1017. doi: 10.1016/j.ymthe.2022.01.044. Epub 2022 Feb 2.

DOI:10.1016/j.ymthe.2022.01.044
PMID:35121107
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8899703/
Abstract

The correct duplication and transfer of genetic material to daughter cells is the major event of cell division. Dysfunction of DNA replication or chromosome segregation presents challenges in cancer initiation and development as well as opportunities for cancer treatment. Cyclic GMP-AMP synthase (cGAS) of the innate immune system detects cytoplasmic DNA and mediates downstream immune responses through the molecule stimulator of interferon genes (STING). However, how cytosolic DNA sensor cGAS participates in guaranteeing accurate cell division and preventing tumorigenesis is still unclear. Recent evidence indicates malfunction of cGAS/STING pathway in cancer progression. Cell cycle-targeted therapy synergizes with immunotherapy via cGAS/STING activation, leading to promising therapeutic benefit. Here, we review the interactions between cell cycle regulation and cGAS/STING signaling, thus enabling us to understand the role of cGAS/STING in cancer initiation, development, and treatment.

摘要

正确的遗传物质复制和传递到子细胞是细胞分裂的主要事件。DNA 复制或染色体分离功能障碍在癌症的发生和发展中带来了挑战，同时也为癌症治疗提供了机会。先天免疫系统中的环鸟苷酸-腺苷酸合成酶 (cGAS) 检测细胞质 DNA，并通过干扰素基因刺激物 (STING) 分子介导下游免疫反应。然而，细胞溶质 DNA 传感器 cGAS 如何参与保证准确的细胞分裂和预防肿瘤发生仍然不清楚。最近的证据表明，cGAS/STING 通路在癌症进展中的功能障碍。细胞周期靶向治疗通过 cGAS/STING 的激活与免疫疗法协同作用，带来了有前景的治疗益处。在这里，我们综述了细胞周期调控与 cGAS/STING 信号之间的相互作用，从而使我们能够理解 cGAS/STING 在癌症发生、发展和治疗中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f2/8899703/cc0b2522f4c2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f2/8899703/fe5a1623c283/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f2/8899703/bc09064c1cb9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f2/8899703/e004f9d92ec6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f2/8899703/78cd2f16e788/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f2/8899703/cc0b2522f4c2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f2/8899703/fe5a1623c283/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f2/8899703/bc09064c1cb9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f2/8899703/e004f9d92ec6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f2/8899703/78cd2f16e788/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5f2/8899703/cc0b2522f4c2/gr4.jpg

相似文献

[1]
cGAS/STING cross-talks with cell cycle and potentiates cancer immunotherapy.

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

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Bibliometric insights into the cell cycle, aging, and metabolism: from molecular mechanisms to clinical implications.

Biogerontology. 2025-7-8

[2]
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Hum Genomics. 2025-6-28

[3]
Progress of Immune-Inducible Biomaterials for Post-Ablation Cancers.

Adv Healthc Mater. 2025-8

[4]
Conjugated STING agonists.

Mol Ther Nucleic Acids. 2025-3-31

[5]
The cGAS-STING-related signature affects the prognosis of colorectal cancer through its regulation of multiple immune cells.

IUBMB Life. 2025-3

[6]
Nuclear translocation of CDK5RAP3 regulated by NXF3 promotes the progression of gastric cancer.

Cell Mol Life Sci. 2025-3-3

[7]
SKP2 inhibition activates tumor cell-intrinsic immunity by inducing DNA replication stress and genomic instability.

Br J Cancer. 2025-1

[8]
Recent advancements in cGAS-STING activation, tumor immune evasion, and therapeutic implications.

Med Oncol. 2024-10-18

[9]
Epigenome-wide association study of prostate cancer in African American men identified differentially methylated genes.

Cancer Med. 2024-8

[10]
Targeting YES1 Disrupts Mitotic Fidelity and Potentiates the Response to Taxanes in Triple-Negative Breast Cancer.

Cancer Res. 2024-11-4

本文引用的文献

[1]
Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer.

Mol Cancer Ther. 2021-12

[2]
Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA.

Mol Pharmacol. 2021-10

[3]
ATR Inhibition Induces CDK1-SPOP Signaling and Enhances Anti-PD-L1 Cytotoxicity in Prostate Cancer.

Clin Cancer Res. 2021-9-1

[4]
Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress.

Mol Cell. 2021-5-20

[5]
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.

Mol Cell. 2021-2-18

[6]
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis.

Science. 2021-3-19

[7]
ER-directed TREX1 limits cGAS activation at micronuclei.

Mol Cell. 2021-2-18

[8]
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.

Cell Rep. 2021-1-5

[9]
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.

Cancer Cell. 2021-1-11

[10]
DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity.

Cancer Cell. 2021-1-11

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