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饮食模式能否预防认知障碍并降低阿尔茨海默病风险:探究作用的潜在机制。

Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects.

机构信息

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China.

出版信息

Neurosci Biobehav Rev. 2022 Apr;135:104556. doi: 10.1016/j.neubiorev.2022.104556. Epub 2022 Feb 3.


DOI:10.1016/j.neubiorev.2022.104556
PMID:35122783
Abstract

Alzheimer's disease (AD) is one of the fastest growing cognitive decline-related neurological diseases. To date, effective curative strategies have remained elusive. A growing body of evidence indicates that dietary patterns have significant effects on cognitive function and the risk of developing AD. Previous studies on the association between diet and AD risk have mainly focused on individual food components and specific nutrients, and the mechanisms responsible for the beneficial effects of dietary patterns on AD are not well understood. This article provides a comprehensive overview of the effects of dietary patterns, including the Mediterranean diet (MedDiet), dietary approaches to stop hypertension (DASH) diet, Mediterranean-DASH diet intervention for neurological delay (MIND), ketogenic diet, caloric restriction, intermittent fasting, methionine restriction, and low-protein and high-carbohydrate diet, on cognitive impairment and summarizes the underlying mechanisms by which dietary patterns attenuate cognitive impairment, especially highlighting the modulation of dietary patterns on cognitive impairment through gut microbiota. Furthermore, considering the variability in individual metabolic responses to dietary intake, we put forward a framework to develop personalized dietary patterns for people with cognitive disorders or AD based on individual gut microbiome compositions.

摘要

阿尔茨海默病(AD)是增长最快的与认知能力下降相关的神经退行性疾病之一。迄今为止,仍缺乏有效的治疗策略。越来越多的证据表明,饮食模式对认知功能和 AD 发病风险有显著影响。先前关于饮食与 AD 风险之间关联的研究主要集中在单一食物成分和特定营养素上,而饮食模式对 AD 有益影响的机制尚不清楚。本文全面综述了饮食模式(包括地中海饮食、得舒饮食、MIND 饮食、生酮饮食、热量限制、间歇性禁食、蛋氨酸限制以及低蛋白高碳水化合物饮食)对认知障碍的影响,并总结了饮食模式减轻认知障碍的潜在机制,特别是强调了饮食模式通过肠道微生物群调节认知障碍的作用。此外,鉴于个体对饮食摄入的代谢反应存在差异,我们提出了一个框架,根据个体肠道微生物组组成,为认知障碍或 AD 患者制定个性化的饮食模式。

相似文献

[1]
Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects.

Neurosci Biobehav Rev. 2022-4

[2]
The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer's Disease-A Review.

Adv Nutr. 2019-11-1

[3]
Diet and Inflammation in Cognitive Ageing and Alzheimer's Disease.

Curr Nutr Rep. 2019-6

[4]
Dietary Patterns and Cognitive Decline: key features for prevention.

Curr Pharm Des. 2019

[5]
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) study: Rationale, design and baseline characteristics of a randomized control trial of the MIND diet on cognitive decline.

Contemp Clin Trials. 2021-3

[6]
Relationships of Dietary Patterns, Foods, and Micro- and Macronutrients with Alzheimer's Disease and Late-Life Cognitive Disorders: A Systematic Review.

J Alzheimers Dis. 2017

[7]
Mediterranean and MIND Diets Containing Olive Biophenols Reduces the Prevalence of Alzheimer's Disease.

Int J Mol Sci. 2019-6-7

[8]
Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment.

EBioMedicine. 2019-8-30

[9]
Dietary Patterns and Cognitive Health in Older Adults: A Systematic Review.

J Alzheimers Dis. 2019

[10]
MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study.

Alzheimers Dement. 2019-2-28

引用本文的文献

[1]
Effects of Dietary Interventions on Cognitive Outcomes.

Nutrients. 2025-6-9

[2]
Mechanisms of interventions targeting modifiable factors for dementia risk reduction.

Mol Neurodegener. 2025-6-23

[3]
Meal scheduling corrects obesogenic diet induced-uncoupling of cortico-hippocampal activities supporting memory.

EBioMedicine. 2025-6-16

[4]
Adherence to an anti-inflammatory diet is associated with lower Alzheimer's disease mortality: A modifiable risk factor in a national cohort.

J Prev Alzheimers Dis. 2025-9

[5]
How the Dietary Saturated/Monounsaturated Fatty Acid Ratio Modulates Brain Function in Older Adults.

Nutrients. 2025-5-31

[6]
Dose-response relationship of egg consumption with cognitive function in rural older adults: a large-scale population-based study.

Front Nutr. 2025-5-20

[7]
Association of serum 25(OH)D3 and cognitive levels with biological aging in the elderly: a cross-sectional study.

Front Nutr. 2025-5-12

[8]
Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies-A Narrative Review.

Int J Mol Sci. 2025-5-1

[9]
Dietary Factors and Cognitive Function: with a Focus on Subjective Cognitive Decline.

Curr Nutr Rep. 2025-4-26

[10]
Comparative Analysis of Egg Yolk Phospholipid Unsaturation and Its Impact on Neural Health in Alzheimer Disease Mice.

Foods. 2025-2-26

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