农村老年人鸡蛋摄入量与认知功能的剂量反应关系：一项基于大规模人群的研究。

Dose-response relationship of egg consumption with cognitive function in rural older adults: a large-scale population-based study.

作者信息

Ren Tingyun, Yuchi Yinghao, Feng Lange, Wang Xinlai, Liao Wei, Tian Zhenzhen, Zhang Huanxiang, Tian Yuan, Li Yuqian, Wang Chongjian

机构信息

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.

Department of Clinical Pharmacology, School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, China.

出版信息

Front Nutr. 2025 May 20;12:1566659. doi: 10.3389/fnut.2025.1566659. eCollection 2025.

DOI:10.3389/fnut.2025.1566659

PMID:40463463

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12129797/

Abstract

BACKGROUND

Previous studies had accessed the effect of egg consumption on cognitive function, but the general population-based evidence is limited and inconclusive. In addition, the optimal intake of egg remains unclear. The study aimed to investigate the association of egg consumption with mild cognitive impairment (MCI) in rural adults and then explore the recommended intake of eggs.

METHODS

This study included 14,550 participants from the second wave of the Henan Rural Cohort Study. Egg consumption was assessed using a validated food frequency questionnaire. Cognitive function was measured using the Mini-Mental State Examination (MMSE). MCI was defined as MMSE scores ≤ 17 for illiteracy, ≤ 20 for primary school education, or ≤ 24 for junior high school education or higher. Logistic regression analyzed the relationship between egg intake and MCI. Dose-response relationships were evaluated using restricted cubic spline (RCS) models.

RESULTS

The adjusted odds ratio () and 95% confidence interval () of per SD increase of daily egg consumption for MCI was 0.925 (0.891, 0.960). A U-shape dose-response relationship between egg consumption and MCI was found ( < 0.001), and the optimal egg intake was 87.94 g/day. The further analysis showed that (95%CI) per SD increase of egg consumption below and above the optimal intake (87.94 g/day) was 0.826 (0.774, 0.880) and 1.188 (1.056, 1.336), respectively. Sensitivity analyses showed similar results.

CONCLUSION

Egg consumption is associated with cognitive function among rural populations and eat egg 87.94 g/day could have best benefit, supporting its potential role in dietary strategies for cognitive health.

摘要

背景

先前的研究已评估了食用鸡蛋对认知功能的影响，但基于普通人群的证据有限且尚无定论。此外，鸡蛋的最佳摄入量仍不明确。本研究旨在调查农村成年人食用鸡蛋与轻度认知障碍（MCI）之间的关联，进而探索鸡蛋的推荐摄入量。

方法

本研究纳入了来自河南农村队列研究第二轮的14550名参与者。使用经过验证的食物频率问卷评估鸡蛋摄入量。使用简易精神状态检查表（MMSE）测量认知功能。MCI定义为文盲的MMSE分数≤17，小学学历者≤20，初中学历及以上者≤24。采用逻辑回归分析鸡蛋摄入量与MCI之间的关系。使用受限立方样条（RCS）模型评估剂量反应关系。

结果

每日鸡蛋摄入量每增加一个标准差（SD），MCI的调整优势比（OR）及95%置信区间（CI）为0.925（0.891，0.960）。发现鸡蛋摄入量与MCI之间呈U形剂量反应关系（P<0.001），最佳鸡蛋摄入量为87.94克/天。进一步分析表明，低于和高于最佳摄入量（87.94克/天）时，鸡蛋摄入量每增加一个标准差，OR（95%CI）分别为0.826（0.774，0.880）和1.188（1.056，1.336）。敏感性分析显示了相似的结果。