School of Biomedical Engineering, Dalian University of Technology, Key Laboratory for Integrated Circuit and Biomedical Electronic System of Liaoning Province, Dalian 116024, China.
School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin 124221, China.
Acta Histochem. 2022 Feb;124(2):151859. doi: 10.1016/j.acthis.2022.151859. Epub 2022 Feb 3.
Several cytoskeleton proteins interact with raft proteins to form raft-cytoskeleton binding protein complexes (RCPCs) that control cell migration and adhesion. The purpose of this paper is to review the latest research on the modes and mechanisms by which a RCPC controls different cellular functions. This paper discusses RCPC composition and its role in cytoskeleton reorganization, as well as the latest developments in molecular mechanisms that regulate cell adhesion and migration under normal conditions. In addition, the role of some external stimuli (such as stress and chemical signals) in this process is further debated, and meanwhile potential mechanisms for RCPC to regulate lipid raft fluidity is proposed. Thus, this review mainly contributes to the understanding of RCPC signal transduction in cells. Additionally, the targeted signal transduction of RCPC and its mechanism connection with cell behaviors will provide a logical basis for the development of unified interventions to combat metastasis related dysfunction and diseases.
几种细胞骨架蛋白与筏蛋白相互作用，形成筏细胞骨架结合蛋白复合物（RCPC），控制细胞迁移和黏附。本文的目的是综述 RCPC 控制不同细胞功能的模式和机制的最新研究。本文讨论了 RCPC 的组成及其在细胞骨架重排中的作用，以及在正常条件下调节细胞黏附和迁移的分子机制的最新进展。此外，还进一步讨论了一些外部刺激（如应激和化学信号）在这一过程中的作用，同时提出了 RCPC 调节脂筏流动性的潜在机制。因此，本综述主要有助于理解细胞中 RCPC 的信号转导。此外，RCPC 的靶向信号转导及其与细胞行为的机制联系为对抗转移相关功能障碍和疾病的统一干预措施的发展提供了逻辑基础。
