Srikanta S, Krisch K, Eisenbarth G S
Diabetes. 1986 Mar;35(3):300-5. doi: 10.2337/diab.35.3.300.
A monoclonal islet cell antibody, HISL-19, reactive with human, bovine, and porcine pancreatic islets has been used to identify and characterize a novel group of islet cell proteins (p120, p69, p67, and p56). Besides the islets, HISL-19-reactive antigenic determinants are also expressed on selected cell types, namely, gut endocrine cells, thyroid parafollicular cells (p120), anterior pituitary cells (p40 and p24), specific hypothalamic neuroendocrine cells, and a single layer of large pyramidal cells of the cerebral cortex, thus defining a new family of neuroendocrine molecules.
一种与人类、牛和猪胰岛发生反应的单克隆胰岛细胞抗体HISL-19，已被用于鉴定和表征一组新的胰岛细胞蛋白（p120、p69、p67和p56）。除了胰岛之外，HISL-19反应性抗原决定簇也在特定细胞类型上表达，即肠道内分泌细胞、甲状腺滤泡旁细胞（p120）、垂体前叶细胞（p40和p24）、特定的下丘脑神经内分泌细胞以及大脑皮层的单层大锥体细胞，从而定义了一个新的神经内分泌分子家族。
