Shenzhen Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
Shenzhen Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China; Post-Doctoral Research Center, Longgang Central Hospital of Shenzhen, Guangdong, China.
Int J Cardiol. 2022 Apr 1;352:180-187. doi: 10.1016/j.ijcard.2022.01.071. Epub 2022 Feb 4.
The left and right atrial (LA and RA) size and function are tightly linked to the morbidity and mortality of multiple cardiovascular diseases. We aimed to establish cardiovascular magnetic resonance (CMR) reference values for LA and RA volumes and phasic function based on a large sample of healthy Chinese adults.
408 validated healthy Chinese adults (54% men; aged 21-70 years) were included. LA and RA maximum, minimum, and pre-atrial contraction volumes (Vmax, Vmin, and Vpac); total, passive, and booster emptying fractions (EF total, EF passive, and EF booster); and total, passive, and active emptying volumes (TEV, PEV, and AEV) were measured on cine CMR. Normal reference values were calculated and were stratified by sex and age decades.
Men demonstrated greater LAVmax, LAVmin, LAVpac, LAPEV, RAVmax, RAVmin, RAVpac, RATEV, and RAAEV, while women had higher LAEF total, LAEF booster, RAEF total, RAEF passive, and RAEF booster (all p < 0.05). Age was positively correlated with LAVpac and RAVpac in both sexes but was positively correlated with LAVmax, LAVmin, RAVmax, and RAVmin only in women (all p < 0.05). For both sexes, aging was associated with decreased LAEF total, LAEF passive, RAEF total, and RAEF passive, but increased LAEF booster (all p < 0.05).
We systematically provide age- and sex-specific CMR reference values for LA and RA volumes and phasic function based on a large sample of healthy Chinese adults with a wide age range. Both age and sex are closely associated with biatrial volumes and function.
左心房（LA）和右心房（RA）的大小和功能与多种心血管疾病的发病率和死亡率密切相关。我们旨在基于大量健康的中国成年人样本，建立左心房和右心房容积和时相功能的心血管磁共振（CMR）参考值。
共纳入 408 例经证实的健康中国成年人（54%为男性；年龄 21-70 岁）。在电影 CMR 上测量 LA 和 RA 的最大、最小和心房收缩前容积（Vmax、Vmin 和 Vpac）；总射血分数（EFtotal）、被动射血分数（EFpassive）和助推射血分数（EFbooster）；以及总排空量（TEV）、被动排空量（PEV）和主动排空量（AEV）。计算并按性别和年龄十年分层得出正常参考值。
男性的 LAVmax、LAVmin、LAVpac、LAPEV、RAVmax、RAVmin、RAVpac、RATEV 和 RAAEV 更大，而女性的 LAEFtotal、LAEFbooster、RAEFtotal、RAEFpassive 和 RAEFbooster 更高（均 p<0.05）。年龄与两性的 LAVpac 和 RAVpac 均呈正相关，但仅在女性中与 LAVmax、LAVmin、RAVmax 和 RAVmin 呈正相关（均 p<0.05）。对于两性，随增龄 LAEFtotal、LAEFpassive、RAEFtotal 和 RAEFpassive 降低，但 LAEFbooster 增加（均 p<0.05）。
我们基于大样本、年龄范围广泛的健康中国成年人，系统地提供了左心房和右心房容积和时相功能的年龄和性别特异性 CMR 参考值。年龄和性别均与双心房容积和功能密切相关。
