利用小鼠Itys/s基因型所需的鼠伤寒沙门氏菌毒力基因。
Salmonella typhimurium virulence genes necessary to exploit the Itys/s genotype of the mouse.
作者信息
Benjamin W H, Turnbough C L, Posey B S, Briles D E
出版信息
Infect Immun. 1986 Mar;51(3):872-8. doi: 10.1128/iai.51.3.872-878.1986.
Abstract
The studies described in this paper provide evidence that the pathogenesis of Salmonella typhimurium in mice is dependent on interactions between particular genotypes of the infected mice and the infecting Salmonella strain. This conclusion was based on data obtained by infecting a panel of BXD recombinant inbred mice with each of three S. typhimurium strains. One of the S. typhimurium strains was a transconjugant (WB500) produced in an interrupted mating between the two other strains, one (SR-11) of high and the other (LT2-Z) of low virulence for BALB/c mice. We found that strain WB500 appeared to have inherited from SR-11 a gene (or genes) which was required to exploit the Itys/s genotype in mice. However, WB500 apparently lacked other SR-11 virulence gene(s), whose effect on the in vivo growth of SR-11 was independent of the Ity genotype of the mouse.
摘要
本文所述的研究提供了证据，表明鼠伤寒沙门氏菌在小鼠体内的发病机制取决于受感染小鼠的特定基因型与感染的沙门氏菌菌株之间的相互作用。这一结论是基于用三种鼠伤寒沙门氏菌菌株分别感染一组BXD重组近交系小鼠所获得的数据。其中一种鼠伤寒沙门氏菌菌株是通过另外两种菌株之间的中断杂交产生的转接合子（WB500），另外两种菌株中，一种（SR-11）对BALB/c小鼠的毒力高，另一种（LT2-Z）对BALB/c小鼠的毒力低。我们发现，WB500菌株似乎从SR-11继承了一个（或几个）基因，该基因是在小鼠中利用Itys/s基因型所必需的。然而，WB500显然缺乏其他SR-11毒力基因，这些基因对SR-11体内生长的影响独立于小鼠的Ity基因型。
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