Shi Xiaohan, Xie Xiaochuan, Jia Yingxian, Li Shangwei
Division of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, China.
Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
J Obstet Gynaecol Res. 2016 Jul;42(7):844-54. doi: 10.1111/jog.13002. Epub 2016 Apr 20.
Recently, the roles of insulin receptor (INSR) and insulin receptor substrate (IRS) polymorphisms in polycystic ovary syndrome (PCOS) have been extensively studied, with conflicting results. Therefore, we conducted the present systematic review and meta-analysis to better evaluate associations of INSR and IRS polymorphisms with PCOS.
We searched PubMed, Medline, EMBASE, Google Scholar and China National Knowledge Infrastructure for eligible articles up to December 2015. Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate associations of INSR and IRS polymorphisms with PCOS.
A total of 28 articles including 2975 PCOS patients and 3011 control subjects were analyzed. The overall analyses and subgroup analyses revealed that IRS-1 Gly972Arg polymorphism was significantly associated with PCOS for the Caucasian population in GG versus GA (OR = 0.57, 95%CI 0.37-0.89), GG versus GA + AA (OR = 0.57, 95%CI 0.36-0.89), GA versus GG + AA (OR = 1.74, 95%CI 1.13-2.69) and G versus A (OR = 0.63 95%CI 0.43-0.92). Also, IRS-2 Gly1057Asp polymorphism was significantly associated with PCOS for the Asian ethnicity in GG versus GA (OR = 0.45, 95%CI 0.24-0.83), GG versus AA (OR = 0.32, 95%CI 0.19-0.53), GG versus GA + AA (OR = 0.35, 95%CI 0.21-0.57), AA versus GG + GA (OR = 2.14, 95%CI 1.43-3.20), and G versus A (OR = 0.43, 95%CI 0.32-0.58). However, we detected no significant association between INSR His 1058 C/T polymorphism and PCOS.
Our findings suggest that IRS-1 Gly972Arg polymorphism is associated with PCOS in the Caucasian ethnicity, and IRS-2 Gly1057Asp polymorphism is correlated with PCOS in the Asian ethnicity. However, INSR His 1058 C/T polymorphism may not be implicated in PCOS. © 2016 Japan Society of Obstetrics and Gynecology.
近年来，胰岛素受体（INSR）和胰岛素受体底物（IRS）基因多态性在多囊卵巢综合征（PCOS）中的作用已得到广泛研究，但结果相互矛盾。因此，我们进行了本系统评价和荟萃分析，以更好地评估INSR和IRS基因多态性与PCOS的关联。
我们检索了截至2015年12月的PubMed、Medline、EMBASE、谷歌学术和中国知网，以查找符合条件的文章。采用比值比（OR）和95%置信区间（CI）来评估INSR和IRS基因多态性与PCOS的关联。
共分析了28篇文章，包括2975例PCOS患者和3011例对照受试者。总体分析和亚组分析显示，对于白种人群，IRS-1 Gly972Arg基因多态性在GG与GA比较时（OR = 0.57，95%CI 0.37 - 0.89）、GG与GA + AA比较时（OR = 0.57，95%CI 0.36 - 0.89）、GA与GG + AA比较时（OR = 1.74，95%CI 1.13 - 2.69）以及G与A比较时（OR = 0.63，95%CI 0.43 - 0.92）与PCOS显著相关。此外，对于亚洲人种，IRS-2 Gly1057Asp基因多态性在GG与GA比较时（OR = 0.45，95%CI 0.24 - 0.83）、GG与AA比较时（OR = 0.32，95%CI 0.19 - 0.53）、GG与GA + AA比较时（OR = 0.35，95%CI 0.21 - 0.57）、AA与GG + GA比较时（OR = 2.14，95%CI 1.43 - 3.20）以及G与A比较时（OR = 0.43，95%CI 0.32 - 0.58）与PCOS显著相关。然而，我们未检测到INSR His 1058 C/T基因多态性与PCOS之间存在显著关联。
我们的研究结果表明，IRS-1 Gly972Arg基因多态性与白种人PCOS相关，IRS-2 Gly1057Asp基因多态性与亚洲人种PCOS相关。然而，INSR His 1058 C/T基因多态性可能与PCOS无关。© 2016日本妇产科学会。
