School of Medicine - La Timone Medical Campus, Aix-Marseille University, UR 3279: CEReSS - Health Service Research and Quality of Life Center, 13005Marseille, France.
Department of Clinical Research and Innovation, Epidemiology and Economic Evaluation Unit, Assistance Publique - Hôpitaux de Marseille, APHM, 13005Marseille, France.
Epidemiol Psychiatr Sci. 2022 Feb 7;31:e14. doi: 10.1017/S2045796022000026.
Housing First (HF), a recovery-oriented approach, was proven effective in stabilising housing situations of homeless individuals with severe mental disorders, yet had limited effectiveness on recovery outcomes on a short-term basis compared to standard treatment. The objective was to assess the effects of the HF model among homeless people with high support needs for mental and physical health services on recovery, housing stability, quality of life, health care use, mental symptoms and addiction issues on 4 years of data from the Un Chez Soi d'Abord trial.
A multicentre randomised controlled trial was conducted from August 2011 to April 2018 with intent-to-treat analysis in four French cities: Lille, Marseille, Paris and Toulouse. Participants were homeless or precariously-housed patients with a DSM-IV-TR diagnosis of bipolar disorder or schizophrenia. Two groups were compared: the HF group (n = 353) had immediate access to independent housing and support from the assertive community treatment team; the Treatment-As-Usual (TAU) group (n = 350) had access to existing support and services. Main outcomes were personal recovery (Recovery Assessment Scale (RAS) scale), housing stability, quality of life (S-QoL), global physical and mental status (Medical Outcomes Study 36-item Short Form Health Survey (SF-36)), inpatient days, mental symptoms (Modified Colorado Symptom Index (MCSI)) and addictions (Mini International Neuropsychiatric Interview (MINI) and Alcohol Use Disorders Identification Test (AUDIT)). Mixed models using longitudinal and cluster designs were performed and adjusted to first age on the street, gender and mental disorder diagnosis. Models were tested for time × group and site × time interactions.
The 703 participants [123 (18%) female] had a mean age of 39 years (95% CI 38.0-39.5 years). Both groups improved RAS index from baseline to 48 months, with no statistically significant changes found between the HF and TAU groups over time. HF patients exhibited better autonomy (adjusted β = 2.6, 95% CI 1.2-4.1) and sentimental life (2.3, 95% CI 0.5-4.1), higher housing stability (28.6, 95% CI 25.1-32.1), lower inpatient days (-3.14, 95% CI -5.2 to -1.1) and improved SF-36 mental composite score (-0.8, 95% CI -1.6 to -0.1) over the 4-year follow-up. HF participants experienced higher alcohol consumption between baseline and 48 months. No significant differences were observed for self-reported mental symptoms or substance dependence.
Data at 4 years were consistent with 2-year follow-up data: similar improvement in personal recovery outcomes but higher housing stability, autonomy and lower use of hospital services in the HF group compared to the TAU group, with the exception of an ongoing alcohol issue. These sustained benefits support HF as a valuable intervention for the homeless patients with severe mental illness.
ClinicalTrials.gov identifier: NCT01570712.
住房优先(HF)是一种以康复为导向的方法,已被证明在稳定严重精神障碍的无家可归者的住房状况方面是有效的,但与标准治疗相比,在短期基础上对康复结果的影响有限。本研究旨在评估在法国四个城市(里尔、马赛、巴黎和图卢兹)进行的 Un Chez Soi d'Abord 试验的 4 年数据中,对需要精神和身体健康服务高支持的无家可归者实施 HF 模式对康复、住房稳定、生活质量、医疗保健使用、心理健康症状和成瘾问题的影响。
这是一项多中心随机对照试验,于 2011 年 8 月至 2018 年 4 月进行,意向治疗分析在四个法国城市进行:里尔、马赛、巴黎和图卢兹。参与者为患有 DSM-IV-TR 双相情感障碍或精神分裂症诊断的无家可归者或住房不稳定者。比较了两组:HF 组(n=353)立即获得独立住房和强化社区治疗团队的支持;治疗常规组(TAU)(n=350)可获得现有支持和服务。主要结局是个人康复(康复评估量表(RAS)量表)、住房稳定、生活质量(S-QoL)、总体身体和心理健康状况(医疗结果研究 36 项简短健康调查问卷(SF-36))、住院天数、心理健康症状(改良科罗拉多症状指数(MCSI))和成瘾(迷你国际神经精神访谈(MINI)和酒精使用障碍识别测试(AUDIT))。使用纵向和聚类设计进行混合模型,并根据首次街头年龄、性别和精神障碍诊断进行调整。测试了时间×组和地点×时间交互作用。
703 名参与者[123 名(18%)女性]的平均年龄为 39 岁(95%CI 38.0-39.5 岁)。两组的 RAS 指数均从基线改善到 48 个月,HF 组和 TAU 组之间在随访期间没有发现统计学上的显著变化。HF 患者表现出更好的自主性(调整后的β=2.6,95%CI 1.2-4.1)和情感生活(2.3,95%CI 0.5-4.1)、更高的住房稳定性(28.6,95%CI 25.1-32.1)、更低的住院天数(-3.14,95%CI-5.2 至-1.1)和改善的 SF-36 心理健康复合评分(-0.8,95%CI-1.6 至-0.1)。HF 组在基线和 48 个月之间有更高的酒精摄入量。未观察到自我报告的心理健康症状或物质依赖的显著差异。
4 年的数据与 2 年的随访数据一致:HF 组在个人康复结果方面有类似的改善,但与 TAU 组相比,HF 组的住房稳定性、自主性和较低的医院服务使用率更高,除了持续存在的酒精问题。这些持续的益处支持 HF 作为一种有价值的干预措施,适用于患有严重精神疾病的无家可归者。
ClinicalTrials.gov 标识符:NCT01570712。