Calik Jacek, Migdal Monika, Zawada Tomasz, Bove Torsten
Old Town Clinic, Wrocław, Poland.
TOOsonix A/S, Hoersholm, Denmark.
Clin Cosmet Investig Dermatol. 2022 Jan 28;15:145-156. doi: 10.2147/CCID.S348106. eCollection 2022.
High intensity focused ultrasound operating at 20 MHz has been demonstrated as a safe and efficient treatment modality for a range of dermatological indications. The method is potentially also applicable to removal of seborrheic keratosis.
A total of 54 seborrheic keratoses in 11 volunteer subjects (8 women and 3 men, average age 51.5 ± 13.2 years) were treated in a single session with a medical 20 MHz high intensity focused ultrasound device developed for dermatological conditions. Handpieces with nominal focal depths of 0.8 mm below the skin surface were used to administer acoustic energy of 0.99-1.2 J/dose. An integrated dermoscope in the handpiece was used to monitor the treatment in real-time. Treatment efficacy and side-effects were assessed directly after treatment and at follow-up 4-15 weeks after treatment.
The treatment showed positive results in 96.3% of the cases. About 68.5% of the cases were classified as complete response and 27.8% of the cases as partial response. Two cases (3.7%) did not respond to treatment and were classified as stable condition. No subjects experienced worsening of their condition, and no treatment received the classification of progressive condition. Side effects were primarily redness in the treatment area due to superficial telangiectasia, mild scarring, and persisting and slow-healing lichen planus-like keratosis. No adverse events were observed.
HIFU is concluded to be a safe and efficient skin treatment for seborrheic keratoses. It has advantages over conventional treatments that can lead to pain during treatment and scarring after healing.
已证明工作频率为20MHz的高强度聚焦超声是一种安全有效的治疗方式，可用于一系列皮肤科适应症。该方法可能也适用于脂溢性角化病的去除。
使用专为皮肤科疾病开发的医用20MHz高强度聚焦超声设备，对11名志愿者受试者（8名女性和3名男性，平均年龄51.5±13.2岁）的总共54处脂溢性角化病进行了单次治疗。使用标称焦深在皮肤表面以下0.8mm的手持探头，以0.99 - 1.2J/剂量的声能进行治疗。手持探头中的集成皮肤镜用于实时监测治疗过程。在治疗后及治疗后4 - 15周的随访中评估治疗效果和副作用。
治疗在96.3%的病例中显示出阳性结果。约68.5%的病例被分类为完全缓解，27.8%的病例为部分缓解。2例（3.7%）对治疗无反应，被分类为病情稳定。没有受试者病情恶化，也没有治疗被分类为病情进展。副作用主要是由于浅表毛细血管扩张导致的治疗区域发红、轻度瘢痕形成，以及持续存在且愈合缓慢的扁平苔藓样角化病。未观察到不良事件。
高强度聚焦超声被认为是一种治疗脂溢性角化病安全有效的皮肤治疗方法。它优于传统治疗方法，传统治疗方法可能在治疗期间导致疼痛以及愈合后形成瘢痕。
