CD123在皮肤红斑狼疮、多形性日光疹、玫瑰糠疹和蕈样肉芽肿中的免疫表达。
CD123 immunoexpression in cutaneous lupus erythematosus, polymorphous light eruption, pityriasis rosea, and mycosis fungoides.
作者信息
Karagun Ebru, Gamsizkan Mehmet, Buyucek Seyma, Coskun Sinem
机构信息
Department of Dermatology, Istinye University, School of Medicine, İstanbul, Turkey.
Department of Pathology, Duzce University, School of Medicine, Duzce, Turkey.
出版信息
Postepy Dermatol Alergol. 2021 Dec;38(6):994-1000. doi: 10.5114/ada.2020.100336. Epub 2022 Jan 7.
INTRODUCTION
CD123-positive plasmacytoid dendrocytes are prominent in the infiltrate of cutaneous lupus erythematous.
AIM
To determine the significance of the CD123 immunostain, which labels plasmacytoid dendritic cells (PDC), in cutaneous lupus erythematous (CLE), polymorphous light eruption (PLE), pityriasis rosea (PR) and mycosis fungoides (MF).
MATERIAL AND METHODS
A total of 76 cases, including MF ( = 27), CLE ( = 19), PR ( = 19), and PLE ( = 11), were included in the study after reviewing their diagnostic clinical features and pathologic findings. The primary antibody against CD123 was performed in all cases.
RESULTS
CD123+ immunostaining in PDCs was positive in all cases. The highest mean percentage was noted in CLE (15.2%), followed by PLE (15%), PR (8.8%), and MF (2%). Besides, the clustering of CD123-positive cells was significant in CLE and PLE compared to MF and PR.
CONCLUSIONS
PDC may have an important role in the aetiology of PLE and CLE cases. CD123 is a useful marker for differentiating CLE and PLE from MF and PR.
引言
CD123阳性浆细胞样树突状细胞在皮肤红斑狼疮浸润中很突出。
目的
确定标记浆细胞样树突状细胞（PDC）的CD123免疫染色在皮肤红斑狼疮（CLE）、多形性日光疹（PLE）、玫瑰糠疹（PR）和蕈样肉芽肿（MF）中的意义。
材料与方法
在回顾76例患者（包括27例MF、19例CLE、19例PR和11例PLE）的诊断临床特征和病理发现后将其纳入研究。所有病例均进行抗CD123一抗检测。
结果
所有病例中PDC的CD123 +免疫染色均为阳性。平均百分比最高的是CLE（15.2%），其次是PLE（15%）、PR（8.8%）和MF（2%）。此外，与MF和PR相比，CLE和PLE中CD123阳性细胞的聚集明显。
结论
PDC可能在PLE和CLE病例的病因学中起重要作用。CD123是将CLE和PLE与MF和PR区分开来的有用标志物。
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