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SAA1、TUB8 失调和单核细胞是伴股骨头坏死的强直性脊柱炎的关键因素。

Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis.

机构信息

The First Clinical Affiliated Hospital of Guangxi Medical University, Nanning, China.

出版信息

Front Immunol. 2022 Jan 18;12:814278. doi: 10.3389/fimmu.2021.814278. eCollection 2021.

DOI:10.3389/fimmu.2021.814278
PMID:35126370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8812255/
Abstract

INTRODUCTION

The mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis.

MATERIALS AND METHODS

The protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis.

RESULTS

SAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P < 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P < 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity.

CONCLUSION

Dysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis.

摘要

简介

强直性脊柱炎合并股骨头坏死的发病机制尚不清楚，本研究旨在探讨遗传和免疫细胞失调对强直性脊柱炎的影响。

材料与方法

采用无标记定量蛋白质组学分析技术对 6 对标本中所有韧带的蛋白质表达进行检测。通过差异蛋白分析、加权基因共表达网络分析、与缺氧相关基因的交集记录、免疫细胞相关性分析和药物敏感性分析，探讨可能的发病机制。最后，收集了 502 例 AS 和 162 例健康对照者的常规血液检查数据，进行免疫细胞差异分析。

结果

这两组间 SAA1 和 TUBA8 的表达差异显著，与巨噬细胞 M0 和静止肥大细胞相关性较强（P < 0.05）。常规血液数据显示，AS 患者的单核细胞表达明显高于健康对照组（P < 0.05）。SAA1 和 TUBA8 与各种药物的敏感性密切相关，可能导致药物敏感性改变。

结论

SAA1、TUBA8 和单核细胞的失调是强直性脊柱炎合并股骨头坏死的关键因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/dc3d2400a2fc/fimmu-12-814278-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/c24fe4e437bd/fimmu-12-814278-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/4b96951c017d/fimmu-12-814278-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/fe4c27f837a6/fimmu-12-814278-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/91615b3f3cdf/fimmu-12-814278-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/0d9aaecb60ff/fimmu-12-814278-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/dc3d2400a2fc/fimmu-12-814278-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/c24fe4e437bd/fimmu-12-814278-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/848d41b81843/fimmu-12-814278-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/de6308a7e9f6/fimmu-12-814278-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/4b96951c017d/fimmu-12-814278-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/fe4c27f837a6/fimmu-12-814278-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/91615b3f3cdf/fimmu-12-814278-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/0d9aaecb60ff/fimmu-12-814278-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22c2/8812255/dc3d2400a2fc/fimmu-12-814278-g008.jpg

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