Noda Y, Hughes R D, Williams R
J Hepatol. 1986;2(1):53-64. doi: 10.1016/s0168-8278(86)80008-3.
The reported cytoprotective effects of prostaglandins against noxious stimuli in the liver was the basis for the present investigations of the effects of prostacyclin (PGI2) and a prostaglandin analogue (BW 245C) in an animal model of severe liver failure. Rats were given galactosamine at two dose levels and the prostaglandins were given in repeated doses from 0 to 6 h during the development of the liver damage or in another group from 24 to 30 h at the time of maximal liver injury. For PGI2 significant cytoprotection was found as assessed by a reduction in blood Normotest at 24, 48 and 72 h (P less than 0.05) and the plasma level of aspartate aminotransferase at 24 and 48 h (P less than 0.02) and the lysosomal markers N-acetyl-beta-glucosaminidase at 24, 48 and 72 h (P less than 0.001) and cathepsin D at 48 h (P less than 0.005) as compared to appropriate controls. Early administration of PGI2 reduced the mortality rate from 63% in the control group to 0% (P less than 0.01) in the treated group, but no significant effects were found when either compound was given later in the 24-h to 30-h period.
前列腺素对肝脏有害刺激具有细胞保护作用的报道是目前关于前列环素（PGI2）和一种前列腺素类似物（BW 245C）在严重肝衰竭动物模型中作用研究的基础。给大鼠注射两种剂量水平的半乳糖胺，在肝损伤发展过程中，从0至6小时重复给予前列腺素；在另一组中，在肝损伤最严重时，于24至30小时给予。对于PGI2，通过24、48和72小时时血液正常试验的降低（P<0.05）、24和48小时时天冬氨酸转氨酶血浆水平的降低（P<0.02）、24、48和72小时时溶酶体标志物N-乙酰-β-葡萄糖苷酶的降低（P<0.001）以及48小时时组织蛋白酶D的降低（P<0.005）来评估，与适当对照组相比，发现有显著的细胞保护作用。早期给予PGI2可使死亡率从对照组的63%降至治疗组的0%（P<0.01），但在24小时至30小时期间后期给予任一化合物时，均未发现显著效果。
