Zahir Ahmed Safia, Cirocchi Nicholas, Saxton Edward, Brown Miss Katherine
Colorectal Department, Luton and Dunstable University Hospital NHS Foundation Trust, United Kingdom.
Ann Med Surg (Lond). 2021 Dec 29;74:103214. doi: 10.1016/j.amsu.2021.103214. eCollection 2022 Feb.
The positive correlation between the incidence of colorectal cancer and age is well known. However, current data demonstrates that there is noticeable age migration in the incidence of colorectal cancer towards young adults highlighting that this disease should no longer be considered to solely affect the elderly. The aim of the study is to analyse the changes in the trend for the age at which colorectal cancer presents, to identify if there is an appreciable age migration towards a younger population.
This is a retrospective observational cohort study on a single-centred population. Data was obtained from The Luton and Dunstable University Hospital Colorectal Cancer Database. It was analysed from three separate decades from the years 1999, 2009, 2019 and 2020. All patients newly diagnosed with colorectal cancer in these time periods were included in this study. Gender, anatomical site, and the stage migration was also analysed.
A total of 598 patients were diagnosed with colorectal cancer in the specified time periods. The overall age-specific incidence rates had risen throughout the three decades. Notably the incidence rate had doubled between 1999 and 2009. In the younger adult population of <40 years, the incidence rate had risen seven-fold across three decades with a disproportionate increase among females compared to males. Stage migration is also analysed over the three decades with no evident difference in anatomical position of the tumour.
There has been an upwards trend in the incidence of colorectal cancer among the younger population. This will have implications for investigation and screening in the future.
结直肠癌发病率与年龄之间的正相关关系众所周知。然而，目前的数据表明，结直肠癌的发病率出现了明显的向年轻成年人转移的趋势，这突出表明这种疾病不应再被认为只影响老年人。本研究的目的是分析结直肠癌发病年龄趋势的变化，以确定是否存在向年轻人群的明显年龄转移。
这是一项针对单中心人群的回顾性观察队列研究。数据来自卢顿和邓斯泰布尔大学医院结直肠癌数据库。对1999年、2009年、2019年和2020年这三个不同十年的数据进行了分析。这些时间段内所有新诊断为结直肠癌的患者均纳入本研究。还分析了性别、解剖部位和分期转移情况。
在指定时间段内，共有598例患者被诊断为结直肠癌。在这三个十年中，总体年龄别发病率均有所上升。值得注意的是，1999年至2009年期间发病率翻了一番。在年龄小于40岁的年轻成年人中，发病率在三个十年中上升了七倍，女性的增长幅度大于男性。还分析了这三个十年中的分期转移情况，肿瘤的解剖位置没有明显差异。
年轻人群中结直肠癌的发病率呈上升趋势。这将对未来的调查和筛查产生影响。
