我们在尿路感染治疗方面还剩下什么？来自伊朗南部的经验。
What Left for Us for Urinary Tract Infection Treatment? An Experience from the South of Iran.
作者信息
Mahmoudi Ali, Moghadami Mohsen, Shirazi Babak, Tabari Parinaz, Moosavi Mahsa
机构信息
Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
The Department of Internal Medicine, Shiraz University of Medical Sciences, Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Adv Biomed Res. 2021 Dec 25;10:52. doi: 10.4103/abr.abr_255_19. eCollection 2021.
BACKGROUND
The aim of the study is to define the prevalence and antimicrobial susceptibility pattern of bacteria from cases of urinary tract infections (UTIs).
MATERIALS AND METHODS
A retrospective analysis of urinary pathogens and their antimicrobial susceptibility was done on urine cultures at Shiraz University Laboratory from 2015 to 2017. Antimicrobial susceptibility tests have done using the disk-diffusion technique as per the standard of CSLI.
RESULTS
During 2 years of study, 3489 samples were culture positive. was the dominant isolate (84%), followed by spp. (10.7%) and spp. (2,2%). The overall resistance rates to trimethoprim-sulfamethoxazole, ceftriaxone, and ciprofloxacin were 56.1%, 47.2%, and 37%, respectively. The most frequently isolated bacteria were , which had resistance rates of 58.6%, 49.1% to TMP-STX, and cefixime, also sensitivity rates of 95.1% to nitrofurantoin (FM).
CONCLUSIONS
In the study area, resistance rates to fluoroquinolones and cephalosporins were high. Because most isolates were sensitive to FM and aminoglycoside, they are suggested as appropriate antimicrobials for empirical treatment of UTIs before available urine culture results.
背景
本研究的目的是确定尿路感染（UTIs）病例中细菌的患病率和抗菌药物敏感性模式。
材料与方法
对设拉子大学实验室2015年至2017年尿液培养中的尿病原体及其抗菌药物敏感性进行回顾性分析。根据CSLI标准，采用纸片扩散技术进行抗菌药物敏感性试验。
结果
在2年的研究期间，3489份样本培养呈阳性。 是主要分离株（84%），其次是 属（10.7%）和 属（2.2%）。对甲氧苄啶-磺胺甲恶唑、头孢曲松和环丙沙星的总体耐药率分别为56.1%、47.2%和37%。最常分离的细菌是 ，其对TMP-STX和头孢克肟的耐药率分别为58.6%、49.1%，对呋喃妥因（FM）的敏感率为95.1%。
结论
在研究区域，对氟喹诺酮类和头孢菌素类的耐药率较高。由于大多数分离株对FM和氨基糖苷类敏感，建议在获得尿液培养结果之前，将它们作为UTIs经验性治疗的合适抗菌药物。
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