McLellan Lisa K, Hunstad David A
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA.
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
Trends Mol Med. 2016 Nov;22(11):946-957. doi: 10.1016/j.molmed.2016.09.003. Epub 2016 Sep 28.
The clinical syndromes comprising urinary tract infection (UTI) continue to exert significant impact on millions of patients worldwide, most of whom are otherwise healthy women. Antibiotic therapy for acute cystitis does not prevent recurrences, which plague up to one fourth of women after an initial UTI. Rising antimicrobial resistance among uropathogenic bacteria further complicates therapeutic decisions, necessitating new approaches based on fundamental biological investigation. In this review, we highlight contemporary advances in the field of UTI pathogenesis and how these might inform both our clinical perspective and future scientific priorities.
构成尿路感染（UTI）的临床综合征继续对全球数百万患者产生重大影响，其中大多数是原本健康的女性。急性膀胱炎的抗生素治疗并不能预防复发，在首次发生UTI后，高达四分之一的女性会受到复发的困扰。尿路致病菌中不断上升的抗菌耐药性使治疗决策更加复杂，因此需要基于基础生物学研究的新方法。在这篇综述中，我们强调了UTI发病机制领域的当代进展，以及这些进展如何为我们的临床观点和未来的科学重点提供参考。
