Croitoru Vlad M, Cazacu Irina M, Popescu Ionut, Paul Doru, Dima Simona Olimpia, Croitoru Adina Emilia, Tanase Alina Daniela
Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania.
Department of Medical Oncology, Fundeni Clinical Institute, Bucharest, Romania.
Front Med (Lausanne). 2022 Jan 21;8:772166. doi: 10.3389/fmed.2021.772166. eCollection 2021.
The use of blood liquid biopsy is increasingly being incorporated into the clinical setting of gastrointestinal cancers care. Clonal hematopoiesis (CH) occurs naturally as a result of the accumulation of somatic mutations and the clonal proliferation of hematopoietic stem cells with normal aging. The identification of CH-mutations has been described as a source of biological noise in blood liquid biopsy. Incorrect interpretation of CH events as cancer related can have a direct impact on cancer diagnosis and treatment. This review summarizes the current understanding of CH as a form of biological noise in blood liquid biopsy and the reported clinical significance of CH in patients with GI cancers.
血液液体活检的应用越来越多地被纳入胃肠道癌症护理的临床环境中。克隆性造血（CH）是随着体细胞突变的积累以及造血干细胞随着正常衰老而发生克隆增殖自然产生的。CH突变的识别被描述为血液液体活检中生物噪声的一个来源。将CH事件错误解读为与癌症相关会对癌症诊断和治疗产生直接影响。本综述总结了目前对CH作为血液液体活检中一种生物噪声形式的理解，以及CH在胃肠道癌症患者中的报道临床意义。
