Guo Rui, Xing Quan Sheng
Qingdao University, Qingdao, China.
Qingdao University-Affiliated Hospital of Women and Children, Qingdao, China.
Epigenet Insights. 2022 Jan 31;15:25168657211064232. doi: 10.1177/25168657211064232. eCollection 2022.
The Wnt family is a large class of highly conserved cysteine-rich secretory glycoproteins that play a vital role in various cellular and physiological courses through different signaling pathways during embryogenesis and tissue homeostasis 3. Wnt5a is a secreted glycoprotein that belongs to the noncanonical Wnt family and is involved in a wide range of developmental and tissue homeostasis. A growing body of evidence suggests that Wnt5a affects embryonic development, signaling through various receptors, starting with the activation of β-catenin by Wnt5a. In addition to affecting planar cell polarity and Ca pathways, β-catenin also includes multiple signaling cascades that regulate various cell functions. Secondly, Wnt5a can bind to Ror receptors to mediate noncanonical Wnt signaling and a significant ligand for Ror2 in vertebrates. Consistent with the multiple functions of Wnt5A/Ror2 signaling, Wnt5A knockout mice exhibited various phenotypic defects, including an inability to extend the anterior and posterior axes of the embryo. Numerous essential roles of Wnt5a/Ror2 in development have been demonstrated. Therefore, Ror signaling pathway become a necessary target for diagnosing and treating human diseases. The Wnt5a- Ror2 signaling pathway as a critical factor has attracted extensive attention.
Wnt家族是一大类高度保守的富含半胱氨酸的分泌型糖蛋白，在胚胎发育和组织稳态过程中，通过不同的信号通路在各种细胞和生理过程中发挥着至关重要的作用3。Wnt5a是一种分泌型糖蛋白，属于非经典Wnt家族，参与广泛的发育和组织稳态。越来越多的证据表明，Wnt5a影响胚胎发育，通过各种受体发出信号，首先是Wnt5a激活β-连环蛋白。除了影响平面细胞极性和Ca途径外，β-连环蛋白还包括多个调节各种细胞功能的信号级联。其次，Wnt5a可以与Ror受体结合，介导非经典Wnt信号，并且是脊椎动物中Ror2的重要配体。与Wnt5A/Ror2信号的多种功能一致，Wnt5A基因敲除小鼠表现出各种表型缺陷，包括无法延长胚胎的前后轴。Wnt5a/Ror2在发育中的许多重要作用已得到证实。因此，Ror信号通路成为诊断和治疗人类疾病的必要靶点。Wnt5a-Ror2信号通路作为一个关键因素已引起广泛关注。
