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Neonatal respiratory syncytial virus infection: role of transplacentally and breast milk-acquired antibodies.新生儿呼吸道合胞病毒感染：经胎盘和母乳获得的抗体的作用
J Virol. 1986 Mar;57(3):1203-6. doi: 10.1128/JVI.57.3.1203-1206.1986.
2
Parenteral immunization with live respiratory syncytial virus is blocked in seropositive cotton rats.在血清阳性的棉鼠中，用活呼吸道合胞病毒进行的肠胃外免疫接种受到阻碍。
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3
Mechanisms of immunity to respiratory syncytial virus in cotton rats.棉鼠对呼吸道合胞病毒的免疫机制。
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Priming for local and systemic antibody memory responses to bovine respiratory syncytial virus: effect of amount of virus, virus replication, route of administration and maternal antibodies.对牛呼吸道合胞病毒的局部和全身抗体记忆反应的启动：病毒量、病毒复制、给药途径和母源抗体的影响
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J Virol. 1993 Mar;67(3):1503-10. doi: 10.1128/JVI.67.3.1503-1510.1993.
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Evolution of protection after maternal immunization for respiratory syncytial virus in cotton rats.母鼠免疫呼吸道合胞病毒后的保护作用演变。
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Br J Exp Pathol. 1988 Aug;69(4):563-75.
7
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8
Immunity to human and bovine respiratory syncytial virus.对人及牛呼吸道合胞病毒的免疫力。
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本文引用的文献

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IMMUNIZATION WITH INACTIVATED MEASLES VIRUS VACCINE: EFFECT OF BOOSTER DOSE AND RESPONSE TO NATURAL CHALLENGE.
Pediatrics. 1965 Jul;36:40-50.
2
Bronchomammary axis in the immune response to respiratory syncytial virus.支气管乳腺轴在对呼吸道合胞病毒的免疫反应中。
J Pediatr. 1981 Aug;99(2):186-91. doi: 10.1016/s0022-3476(81)80447-7.
3
Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level.低收入家庭婴儿感染呼吸道合胞病毒的风险与年龄、性别、种族及母体抗体水平的关系。
J Pediatr. 1981 May;98(5):708-15. doi: 10.1016/s0022-3476(81)80829-3.
4
Breast-feeding and respiratory virus infection.母乳喂养与呼吸道病毒感染。
Pediatrics. 1982 Aug;70(2):239-45.
5
Atypical measles syndrome: pathologic and serologic findings.
Pediatrics. 1982 Aug;70(2):203-9.
6
Five measles virus antigens demonstrated by use of mouse hybridoma antibodies in productively infected tissue culture cells.利用小鼠杂交瘤抗体在产生感染的组织培养细胞中证实的五种麻疹病毒抗原。
Arch Virol. 1982;71(1):1-11. doi: 10.1007/BF01315171.
7
Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies.通过单克隆抗体的被动转移保护棉鼠免受呼吸道合胞病毒感染。
Infect Immun. 1984 Feb;43(2):756-8. doi: 10.1128/iai.43.2.756-758.1984.
8
Mechanisms of immunity to respiratory syncytial virus in cotton rats.棉鼠对呼吸道合胞病毒的免疫机制。
Infect Immun. 1983 Oct;42(1):81-7. doi: 10.1128/iai.42.1.81-87.1983.
9
Monoclonal antibodies to respiratory syncytial virus proteins: identification of the fusion protein.针对呼吸道合胞病毒蛋白的单克隆抗体：融合蛋白的鉴定
J Virol. 1983 Jul;47(1):171-7. doi: 10.1128/JVI.47.1.171-177.1983.
10
Atypical measles in children previously immunized with attenuated measles virus vaccines.曾接种减毒麻疹病毒疫苗的儿童中的非典型麻疹。
Pediatrics. 1972 Nov;50(5):712-7.

新生儿呼吸道合胞病毒感染：经胎盘和母乳获得的抗体的作用

Neonatal respiratory syncytial virus infection: role of transplacentally and breast milk-acquired antibodies.

作者信息

Wong D T, Ogra P L

出版信息

J Virol. 1986 Mar;57(3):1203-6. doi: 10.1128/JVI.57.3.1203-1206.1986.

DOI:10.1128/JVI.57.3.1203-1206.1986
PMID:3512852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC252862/
Abstract

The effect of transplacentally and breast milk-acquired antibodies on respiratory syncytial virus infection was studied in neonatal and 2-month-old cotton rats. Adult female rats infected intranasally with live virus regularly produced virus-specific antibodies in the serum, colostrum, and breast milk. By using foster feeding techniques, we showed that both transplacentally and breast milk-acquired antibodies were effective in reducing the replication of respiratory syncytial virus in the lungs of neonatal animals when they were challenged with live virus via the nasal route at 3 days of age. However, the protection provided by these antibodies was rather brief. There was no difference in the replication of respiratory syncytial virus in the lungs of 2-month-old animals that were delivered and nursed by seropositive (immunized) or seronegative (control) cotton rats.

摘要

在新生和2月龄的棉鼠中研究了经胎盘和母乳获得的抗体对呼吸道合胞病毒感染的影响。成年雌性大鼠经鼻内接种活病毒后，血清、初乳和母乳中会定期产生病毒特异性抗体。通过使用代乳喂养技术，我们发现，当新生动物在3日龄经鼻途径用活病毒攻击时，经胎盘和母乳获得的抗体均能有效减少呼吸道合胞病毒在其肺部的复制。然而，这些抗体提供的保护相当短暂。由血清阳性（免疫）或血清阴性（对照）棉鼠分娩和哺育的2月龄动物，其肺部呼吸道合胞病毒的复制没有差异。