新生儿呼吸道合胞病毒感染：经胎盘和母乳获得的抗体的作用
Neonatal respiratory syncytial virus infection: role of transplacentally and breast milk-acquired antibodies.
作者信息
Wong D T, Ogra P L
出版信息
J Virol. 1986 Mar;57(3):1203-6. doi: 10.1128/JVI.57.3.1203-1206.1986.
Abstract
The effect of transplacentally and breast milk-acquired antibodies on respiratory syncytial virus infection was studied in neonatal and 2-month-old cotton rats. Adult female rats infected intranasally with live virus regularly produced virus-specific antibodies in the serum, colostrum, and breast milk. By using foster feeding techniques, we showed that both transplacentally and breast milk-acquired antibodies were effective in reducing the replication of respiratory syncytial virus in the lungs of neonatal animals when they were challenged with live virus via the nasal route at 3 days of age. However, the protection provided by these antibodies was rather brief. There was no difference in the replication of respiratory syncytial virus in the lungs of 2-month-old animals that were delivered and nursed by seropositive (immunized) or seronegative (control) cotton rats.
摘要
在新生和2月龄的棉鼠中研究了经胎盘和母乳获得的抗体对呼吸道合胞病毒感染的影响。成年雌性大鼠经鼻内接种活病毒后，血清、初乳和母乳中会定期产生病毒特异性抗体。通过使用代乳喂养技术，我们发现，当新生动物在3日龄经鼻途径用活病毒攻击时，经胎盘和母乳获得的抗体均能有效减少呼吸道合胞病毒在其肺部的复制。然而，这些抗体提供的保护相当短暂。由血清阳性（免疫）或血清阴性（对照）棉鼠分娩和哺育的2月龄动物，其肺部呼吸道合胞病毒的复制没有差异。
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