通过单克隆抗体的被动转移保护棉鼠免受呼吸道合胞病毒感染。
Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies.
作者信息
Walsh E E, Schlesinger J J, Brandriss M W
出版信息
Infect Immun. 1984 Feb;43(2):756-8. doi: 10.1128/iai.43.2.756-758.1984.
Abstract
The effects of passive administration of neutralizing monoclonal antibodies (MAB) to respiratory syncytial virus glycoproteins (GP90 and VP70) was evaluated in cotton rats challenged with respiratory syncytial virus. Animals injected with MAB to VP70 had lower mean viral titers in lung tissues than did controls (log10 2.5 versus 5.4 PFU/g; P less than 0.001), as did cotton rats given MAB to GP90 (log10 2.1 versus 5.0 PFU/g; P less than 0.001). Fifty percent of animals given either MAB had no detectable virus in lung tissues, whereas virus was detected in the lungs of all controls. Virus growth in nasal turbinates was decreased but not eliminated in recipients of either MAB.
摘要
在受到呼吸道合胞病毒攻击的棉鼠中评估了被动给予中和性单克隆抗体（MAB）针对呼吸道合胞病毒糖蛋白（GP90和VP70）的效果。注射针对VP70的MAB的动物，其肺组织中的平均病毒滴度低于对照组（log10 2.5对5.4 PFU/g；P小于0.001），给予针对GP90的MAB的棉鼠也是如此（log10 2.1对5.0 PFU/g；P小于0.001）。给予任一MAB的动物中，50%在肺组织中未检测到病毒，而所有对照组动物的肺中都检测到了病毒。在接受任一MAB的动物中，鼻甲中的病毒生长有所减少但并未消除。
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本文引用的文献
1
Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level.低收入家庭婴儿感染呼吸道合胞病毒的风险与年龄、性别、种族及母体抗体水平的关系。
J Pediatr. 1981 May;98(5):708-15. doi: 10.1016/s0022-3476(81)80829-3.
2
Parenteral administration of live respiratory syncytial virus vaccine: results of a field trial.呼吸道合胞病毒活疫苗的肠胃外给药：一项现场试验的结果
J Infect Dis. 1982 Mar;145(3):311-9. doi: 10.1093/infdis/145.3.311.
3
The role of viral glycoproteins in adsorption, penetration, and pathogenicity of viruses.病毒糖蛋白在病毒吸附、穿透及致病性中的作用。
Rev Infect Dis. 1980 Jan-Feb;2(1):40-61. doi: 10.1093/clinids/2.1.40.
4
Importance of antibodies to the fusion glycoprotein of paramyxoviruses in the prevention of spread of infection.副粘病毒融合糖蛋白抗体在预防感染传播中的重要性。
J Exp Med. 1980 Feb 1;151(2):275-88. doi: 10.1084/jem.151.2.275.
5
Monoclonal antibodies to respiratory syncytial virus proteins: identification of the fusion protein.针对呼吸道合胞病毒蛋白的单克隆抗体：融合蛋白的鉴定
J Virol. 1983 Jul;47(1):171-7. doi: 10.1128/JVI.47.1.171-177.1983.
6
7
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Am J Epidemiol. 1973 Oct;98(4):289-300. doi: 10.1093/oxfordjournals.aje.a121558.
8
Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine.尽管之前接种了抗原性灭活疫苗，但婴儿仍患呼吸道合胞病毒病。
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9
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10
Role of maternal antibody in pneumonia and bronchiolitis due to respiratory syncytial virus.母体抗体在呼吸道合胞病毒引起的肺炎和细支气管炎中的作用。
J Infect Dis. 1976 Sep;134(3):211-7. doi: 10.1093/infdis/134.3.211.
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