Walsh E E, Schlesinger J J, Brandriss M W
Infect Immun. 1984 Feb;43(2):756-8. doi: 10.1128/iai.43.2.756-758.1984.
The effects of passive administration of neutralizing monoclonal antibodies (MAB) to respiratory syncytial virus glycoproteins (GP90 and VP70) was evaluated in cotton rats challenged with respiratory syncytial virus. Animals injected with MAB to VP70 had lower mean viral titers in lung tissues than did controls (log10 2.5 versus 5.4 PFU/g; P less than 0.001), as did cotton rats given MAB to GP90 (log10 2.1 versus 5.0 PFU/g; P less than 0.001). Fifty percent of animals given either MAB had no detectable virus in lung tissues, whereas virus was detected in the lungs of all controls. Virus growth in nasal turbinates was decreased but not eliminated in recipients of either MAB.
在受到呼吸道合胞病毒攻击的棉鼠中评估了被动给予中和性单克隆抗体（MAB）针对呼吸道合胞病毒糖蛋白（GP90和VP70）的效果。注射针对VP70的MAB的动物，其肺组织中的平均病毒滴度低于对照组（log10 2.5对5.4 PFU/g；P小于0.001），给予针对GP90的MAB的棉鼠也是如此（log10 2.1对5.0 PFU/g；P小于0.001）。给予任一MAB的动物中，50%在肺组织中未检测到病毒，而所有对照组动物的肺中都检测到了病毒。在接受任一MAB的动物中，鼻甲中的病毒生长有所减少但并未消除。
