用甲型流感病毒灭活疫苗对母雪貂进行免疫接种后，新生雪貂被动免疫的产生。
Production of passive immunity in neonatal ferrets following maternal vaccination with killed influenza A virus vaccines.
作者信息
Sweet C, Bird R A, Jakeman K, Coates D M, Smith H
出版信息
Immunology. 1987 Jan;60(1):83-9.
Abstract
Neonatal ferrets may be passively immunized following maternal vaccination with formalin-inactivated influenza A virus vaccine, but the level of protection from partial to complete depends upon the number of doses used to vaccinate the mother, the presence or absence of aluminum hydroxide adjuvant, whether or not the mothers were 'primed' by prior infection with a serologically heterologous type A virus, and the age of the neonate at challenge. Neonates were completely protected up to 2 weeks of age, but susceptibility returned to nasal epithelium at 5 weeks and to lung at 7 weeks. Mothers immunized up to 9 months previously also partially or completely protected their offspring, this correlating with the maternal serum haemagglutination-inhibition (HI) antibody titre at the time of neonatal challenge, not the duration of immunity.
摘要
新生雪貂可在母体接种福尔马林灭活甲型流感病毒疫苗后获得被动免疫，但保护程度从部分保护到完全保护取决于用于给母体接种的剂量数量、是否存在氢氧化铝佐剂、母体是否曾被血清学上异源的甲型病毒预先感染（即“预激发”）以及受攻击时新生雪貂的年龄。新生雪貂在2周龄前可获得完全保护，但在5周龄时鼻上皮恢复易感性，7周龄时肺部恢复易感性。在9个月前接种疫苗的母体也能部分或完全保护其后代，这与新生雪貂受攻击时母体血清血凝抑制（HI）抗体滴度相关，而非免疫持续时间。
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