Zhang Di, Yang Jinghong, Ye Sheng, Wang Yutong, Liu Chuang, Zhang Qianbing, Liu Ruiyuan
Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Small. 2022 Apr;18(13):e2107071. doi: 10.1002/smll.202107071. Epub 2022 Feb 6.
Photothermal therapy has gained widespread attention in cancer treatment, although its efficacy is suppressed due to the inflammatory response and immunosuppression, resulting in a discounted therapeutic effect. In this contribution, a high-performance NIR absorption organic small chromophore is developed, which is encapsulated into Pluronic F-127 to fabricate NIR absorption organic nanoparticles (TTM NPs) with excellent photothermal conversion efficiency (51.49%) for photothermal therapy. TTM NPs based photothermal therapy are combined with Aspisol, a kind of nonsteroidal anti-inflammatory drug, to weaken the inflammation and immunosuppression tumor microenvironment and enhance the antitumor effect. The results prove that the combination therapy realizes effective thermal elimination of primary tumors, inhibition of distant tumors, and suppression of tumor metastasis. The data show that combination therapy can suppress the expression of inflammatory factors, enhance dendritic cell activation and maturation, reverse the immunosuppression, facilitate T cell infiltration, and restore antitumor cytotoxic T lymphocyte activity. This study provides a paradigm to extend the development of photothermal therapy.
光热疗法在癌症治疗中受到了广泛关注，尽管由于炎症反应和免疫抑制其疗效受到抑制，导致治疗效果大打折扣。在本研究中，开发了一种高性能近红外吸收有机小分子发色团，将其封装到普朗尼克F-127中，制备出具有优异光热转换效率（51.49%）的近红外吸收有机纳米颗粒（TTM NPs）用于光热疗法。基于TTM NPs的光热疗法与一种非甾体抗炎药阿斯匹林联合使用，以减弱炎症和免疫抑制肿瘤微环境并增强抗肿瘤效果。结果证明，联合疗法实现了对原发性肿瘤的有效热消融、对远处肿瘤的抑制以及对肿瘤转移的抑制。数据表明，联合疗法可抑制炎症因子的表达，增强树突状细胞的激活和成熟，逆转免疫抑制，促进T细胞浸润，并恢复抗肿瘤细胞毒性T淋巴细胞活性。本研究为拓展光热疗法的发展提供了一个范例。
