School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
Department of Orthopedics, Panyu Hospital of Chinese Medicine, Guangzhou, Guangdong, People's Republic of China.
Int J Nanomedicine. 2024 Oct 25;19:10819-10837. doi: 10.2147/IJN.S467419. eCollection 2024.
As a burgeoning cancer treatment modality, photothermal therapy (PTT) has shown robust anti-tumor effects. However, it still faces numerous challenges, such as triggering an inflammatory response and potentially increasing the risk of cancer recurrence. To address these concerns, integration of PTT with anti-inflammatory therapies presents a promising approach to enhance the efficacy of cancer treatment and meanwhile reduce the risk of recurrence.
In this study, Gd was first chelated with dopamine to create Gd-DA chelates, and then the mesoporous dopamine nanoparticles MX@Arg-Gd-MPDA (MAGM NPs) were synthesized by combining arginine (Arg) and the anti-inflammatory medication meloxicam (MX). The photothermal properties of MAGM NPs were then defined and examined; the in vivo MRI imaging effect, as well as MAGM NPs' anti-cancer and anti-inflammatory efficiency, were tested in a mouse model of breast cancer.
The incorporation of Arg doping into MAGM NPs was intended to boost its photothermal conversion efficiency and reactive oxygen species (ROS) scavenging ability. Additionally, synergizing with the anti-inflammatory agent meloxicam (MX) within the nanoparticles aimed to enhance the anti-inflammatory effect following photothermal therapy. Furthermore, gadolinium ions (Gd) were chelated into the nanostructure to enable precise T1-T2 dual-mode magnetic resonance imaging (MRI) of the intratumor accumulation profile. This imaging capability was leveraged to guide the implementation of photothermal therapy. Animal experiments demonstrated that MAGM NPs exerted a notable anticancer effect in a 4T1 breast cancer mouse model, under the precise guidance of MRI.
作为一种新兴的癌症治疗方式，光热疗法（PTT）已显示出强大的抗肿瘤效果。然而，它仍然面临许多挑战，例如引发炎症反应和潜在增加癌症复发的风险。为了解决这些问题，将 PTT 与抗炎治疗相结合是一种很有前途的方法，可以提高癌症治疗的疗效，同时降低复发的风险。
本研究首先将 Gd 与多巴胺螯合，制备 Gd-DA 螯合物，然后通过结合精氨酸（Arg）和抗炎药物美洛昔康（MX）合成介孔多巴胺纳米粒子 MX@Arg-Gd-MPDA（MAGM NPs）。然后定义和检查 MAGM NPs 的光热特性；在乳腺癌小鼠模型中测试了 MAGM NPs 的体内 MRI 成像效果以及 MAGM NPs 的抗癌和抗炎效率。
将 Arg 掺杂到 MAGM NPs 中旨在提高其光热转换效率和清除活性氧（ROS）的能力。此外，在纳米粒子中与抗炎药物美洛昔康（MX）协同作用，旨在增强光热治疗后的抗炎效果。此外，将钆离子（Gd）螯合到纳米结构中，以实现肿瘤内积聚分布的精确 T1-T2 双模磁共振成像（MRI）。这种成像能力被用于指导光热治疗的实施。动物实验表明，在 MRI 的精确指导下，MAGM NPs 在 4T1 乳腺癌小鼠模型中表现出显著的抗癌效果。
