氨基苯酚修饰的金纳米粒子具有最小的耳毒性杀死细菌。
Aminophenol-modified gold nanoparticles kill bacteria with minimal ototoxicity.
机构信息
Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Rd, Nanshan District, Shenzhen, Guangdong 518055, P. R. China.
GBA Research Innovation Institute for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11 Zhongguancun Beiyitiao, Beijing 100190, P. R. China.
出版信息
Chem Commun (Camb). 2022 Feb 24;58(17):2842-2845. doi: 10.1039/d1cc06559a.
We report aminophenol (A)-modified gold nanoparticles (AGNPs), which have potent antibacterial effects against multidrug-resistant bacteria with a broad antibacterial spectrum. Moreover, a series of and models indicate that AGNPs are much less ototoxic than aminoglycosides. AGNPs thus have the potential to replace aminoglycosides as novel antibacterial agents for clinical applications.
我们报告了氨基酚（A）修饰的金纳米粒子（AGNPs），其对具有广谱抗菌作用的多重耐药菌具有强大的抗菌作用。此外，一系列 和 模型表明，AGNPs 的耳毒性远低于氨基糖苷类。因此，AGNPs 有可能替代氨基糖苷类成为临床应用的新型抗菌药物。
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